85092-83-7Relevant articles and documents
Synthesis and anti-tumor activity of marine alkaloids
Zhou, Shiyang,Huang, Gangliang,Chen, Guangying
, (2021/04/15)
Marine alkaloids were divided into five categories from the perspective of anti-tumor activity. The optimization process, chemical synthesis, anti-tumor activity evaluation and structure–activity relationship of various compounds were discussed.
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors
Manzoni, Leonardo,Zucal, Chiara,Maio, Danilo Di,D'Agostino, Vito G.,Thongon, Natthakan,Bonomo, Isabelle,Lal, Preet,Miceli, Marco,Baj, Vanessa,Brambilla, Marta,Cerofolini, Linda,Elezgarai, Saioa,Biasini, Emiliano,Luchinat, Claudio,Novellino, Ettore,Fragai, Marco,Marinelli, Luciana,Provenzani, Alessandro,Seneci, Pierfausto
, p. 1483 - 1498 (2018/03/05)
The human antigen R (HuR) is an RNA-binding protein known to modulate the expression of target mRNA coding for proteins involved in inflammation, tumorigenesis, and stress responses and is a valuable drug target. We previously found that dihydrotanshinone
Simple and efficient procedures for selective preparation of 3-haloindoles and 2,3-dihaloindoles by using 1,3-dibromo-5,5-dimethylhydantoin and 1,3-dichloro-5,5-dimethylhydantoin
Yan, Jianwei,Ni, Tianjun,Yan, Fulin
supporting information, p. 1096 - 1098 (2015/02/19)
Simple and efficient synthetic procedures for the selective preparation of 3-bromo/3-chloroindoles and 2,3-dibromo/2,3-dichloroindoles by using 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) and 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) were developed. Using 1,4-dioxane as the solvent, a variety of indoles, treated with 0.55 equiv DBDMH/DCDMH, afford the corresponding 3-bromo/3-chloroindoles selectively in 82-99% yield. In 1,2-dichloroethane (DCE), a series of 2,3-dichloro/2,3-dibromoindoles were selectively obtained in 84-95% yield by treating with DBDMH/DCDMH. All the processes do not need extra catalysts, dry solvents, or harsh reaction conditions.