85102-26-7

Basic information

• Product Name: 2,3-diphenylimidazo[1,2-a]pyridine
• Synonyms: 2,3-diphenylimidazo[1,2-a]pyridine
• CAS NO: 85102-26-7
• Molecular Formula: C₁₉H₁₄N₂
• Molecular Weight: 270.32786
• Mol File: 85102-26-7.mol
• Article Data: 44

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3-diphenylimidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-diphenylimidazo[1,2-a]pyridine(85102-26-7)
• EPA Substance Registry System: 2,3-diphenylimidazo[1,2-a]pyridine(85102-26-7)

Safety Data

• Hazardous Substances Data: 85102-26-7(Hazardous Substances Data)

Usage

General Description

2,3-diphenylimidazo[1,2-a]pyridine is a chemical compound with a unique structure that consists of an imidazole and a pyridine ring fused together. It is primarily used in medicinal chemistry for the development of new drugs, particularly for its potential anti-cancer and anti-tumor properties. Research has shown that this compound can inhibit the growth of cancer cells and induce cell death in cancerous tissues. Additionally, it has also been studied for its potential anti-inflammatory and antimicrobial properties. Its unique structure and diverse biological activities make it a promising candidate for further development in the field of drug discovery and pharmaceutical research.

Upstream product

• 504-29-0 2-aminopyridine 
• 447-31-4 Desyl chloride 
• 85102-39-2 2-Morpholinomethyl-4,5-diphenyl-1-(2-propynyl)-imidazole 
• 64413-90-7 3-iodo-2-phenylimidazo[1,2-α]pyridine 
• 98-80-6 phenylboronic acid 
• 1484-50-0 desyl bromide 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 41054-03-9 2-Morpholinomethyl-4,5-diphenylimidazole 
• 85102-37-0 1-Benzyl-2-morpholinomethyl-4,5-diphenylimidazole 
• 112581-95-0 2-Bromoimidazo[1,2-a]pyridine 
• 108-86-1 bromobenzene 
• 126202-06-0 2-(2-imino-1,2-dihydropyridin-1-yl)acetic acid 
• 1021019-74-8 imidazo[1,2-a]pyridin-2-yl trifluoromethanesulfonate 
• 4044-95-5 2-Phenyl-3-bromoimidazo<1,2-a>pyridine 

Relevant articles and documents

A multi pathway coupled domino strategy: I2/ TBHP-promoted synthesis of imidazopyridines and thiazoles via sp3, sp2 and sp C-H functionalization

I2/TBHP-promoted, one-pot, multi pathway synthesis of imidazopyridines and thiazoles has been achieved through readily available ethylarenes, ethylenearenes and ethynearenes. I2/TBHP as an initiator and oxidant is used to realize the C-H functionalization of this domino reaction. Simple and available starting materials, wide range of functional group tolerance, high potential for drug activity of the products and application in production are the advantageous features of this method.

Diversity-oriented synthesis toward aryl- And phosphoryl-functionalized imidazo[1,2-a]pyridines

We report herein an efficient synthesis of diversely polysubstituted imidazo[1,2-a]pyridines, a family of aza-heterocycles endowed with numerous biological properties, through a sequence involving two consecutive palladium-catalyzed cross-coupling reactions. First, we demonstrated that a Hirao coupling occurred straightforwardly in high yields at positions 3, 5, and 6 of imidazopyridine derivatives, giving access to a wide variety of substituted phosphonates, phosphinates, and phosphine oxides. In a second step, direct CH-arylation of phosphorylimidazopyridines with aryl halides was found to be effective and fully selective, leading to 3-aryl-substituted imidazopyridines in moderate to high yields depending on steric hindrance.

Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes

Herein, we describe an efficient, rapid and benign protocol for the direct C(sp2)-H bond halogenation (Cl, Br, I) of 2-arylimidazo[1,2-a]pyridines using trihaloisocyanuric acids in ethanol. Furthermore, this sustainable protocol was successfull