851167-14-1Relevant articles and documents
Novel carbamate derivatives of 4-β-amino-4′-O-demethyl-4- desoxypodophyllotoxin as inhibitors of topoisomerase II: Synthesis and biological evaluation
Duca, Maria,Arimondo, Paola B.,Leonce, Stephane,Pierre, Alain,Pfeiffer, Bruno,Monneret, Claude,Dauzonne, Daniel
, p. 1074 - 1080 (2007/10/03)
A novel series of carbamate derivatives of 4-β-amino-4′-O- demethyl-4-desoxypodophyllotoxin were synthesized. Their effect on human DNA topoisomerase II and antiproliferative activity was evaluated. Compounds 4a-c, 4g, 4j and 4k are topoisomerase II poiso