851179-00-5 Usage
Description
3-Chloro-2,5-difluoropyridine is an organic compound characterized by the presence of a chlorine atom at the 3rd position and two fluorine atoms at the 2nd and 5th positions on a pyridine ring. It is a versatile intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its unique structural features and reactivity.
Uses
Used in Pharmaceutical Industry:
3-Chloro-2,5-difluoropyridine is used as a key intermediate for the synthesis of selective protein kinase C theta (PKCθ) inhibitors. These inhibitors are valuable for the treatment of autoimmune diseases, as they help regulate the immune response and reduce inflammation.
Used in Agrochemical Industry:
3-Chloro-2,5-difluoropyridine can also be utilized as a building block in the development of agrochemicals, such as herbicides and insecticides. Its unique structure and reactivity make it a promising candidate for the design of novel and effective compounds targeting specific pests or weeds, thereby improving crop yield and quality.
Check Digit Verification of cas no
The CAS Registry Mumber 851179-00-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,1,1,7 and 9 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 851179-00:
(8*8)+(7*5)+(6*1)+(5*1)+(4*7)+(3*9)+(2*0)+(1*0)=165
165 % 10 = 5
So 851179-00-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H2ClF2N/c6-4-1-3(7)2-9-5(4)8/h1-2H
851179-00-5Relevant articles and documents
Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution
Bobbio, Carla,Rausis, Thierry,Schlosser, Manfred
, p. 1903 - 1910 (2007/10/03)
Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2-4), all six trifluoropyridines (5-10), and the five non-commercial difluoropyridines (11-14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogenation-dediazotation or dehydrochlorination-dediazotation. To introduce an extra fluorine atom, a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.
