85118-33-8

Basic information

• Product Name: 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride
• Synonyms: 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride;THIP HYDROCHLORIDE (GABOXADOL) POST-SYNA PTIC GABA RE;THIP hydrochloride, 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride;Einecs 285-687-7;4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt);Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, Monohydrochloride;Gaboxadol hydrochloride solid, >=98% (HPLC);4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate:hydrochloride
• CAS NO: 85118-33-8
• Molecular Formula: C6H9ClN2O2
• Molecular Weight: 176.60086
• EINECS: 285-687-7
• Mol File: 85118-33-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 236 °C
• Boiling Point: 295.7 °C at 760 mmHg
• Flash Point: 132.6 °C
• Appearance: white/
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: ethanol: soluble0.91mg/mL
• Merck: 14,4321
• CAS DataBase Reference: 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride(85118-33-8)
• EPA Substance Registry System: 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride(85118-33-8)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: NY3396800
• Hazardous Substances Data: 85118-33-8(Hazardous Substances Data)

Usage

Description

4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride, also known as Gaboxadol or THIP, is a GABA site agonist with high affinity for the δ subunit of extrasynaptic high-affinity GABAA receptors. It was initially developed for the treatment of schizophrenia, epilepsy, primary insomnia, and Huntington's disease. Gaboxadol can easily cross the blood-brain barrier and is rapidly absorbed by the body.

Uses

Used in Pharmaceutical Industry:
4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride is used as a GABAergic agonist for the treatment of various neurological disorders such as schizophrenia, epilepsy, primary insomnia, and Huntington's disease. Its agonistic activities towards GABA sites contribute to its therapeutic effects.
Used in Sleep Aid Applications:
4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride is used as a sleep aid drug for the treatment of chronic pain and insomnia. Its agonistic properties towards GABA sites help in promoting sleep and alleviating pain.
Used in Antidepressant Applications:
4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride exhibits antidepressant-like properties through its agonistic activities towards GABA sites, making it a potential candidate for the treatment of depression.
Used in Cancer Research:
4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride, as Gaboxadol hydrochloride, has been used in cell migration and invasion assays to assess liver cancer cell migration, contributing to the understanding of cancer progression and potential therapeutic targets.