851371-60-3

Basic information

• Product Name: Ethanone, 1-(2-furanyl)-2-(4-pyriMidinyl)-
• Synonyms: Ethanone, 1-(2-furanyl)-2-(4-pyriMidinyl)-;1-(2-Furyl)-2-pyrimidin-4-ylethanone
• CAS NO: 851371-60-3
• Molecular Formula: C10H8N2O2
• Molecular Weight: 188.18272
• Mol File: 851371-60-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 128-130℃
• Boiling Point: 351.5°C at 760 mmHg
• Flash Point: 166.4°C
• Appearance: /
• Density: 1.246
• Vapor Pressure: 4.1E-05mmHg at 25°C
• Refractive Index: 1.566
• PKA: 1.31±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 1-(2-furanyl)-2-(4-pyriMidinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-furanyl)-2-(4-pyriMidinyl)-(851371-60-3)
• EPA Substance Registry System: Ethanone, 1-(2-furanyl)-2-(4-pyriMidinyl)-(851371-60-3)

Safety Data

• Hazardous Substances Data: 851371-60-3(Hazardous Substances Data)

Usage

Description

Ethanone, 1-(2-furanyl)-2-(4-pyrimidinyl)-, also known as 1-(2-furyl)-2-(4-pyrimidinyl)ethanone, is a heterocyclic chemical compound with the molecular formula C13H11N3O. It features a furanyl group and a pyrimidinyl group, which contribute to its unique chemical structure and properties. Ethanone, 1-(2-furanyl)-2-(4-pyrimidinyl)is known for its potential biological activity and is being explored for its applications in the pharmaceutical and agrochemical industries.

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(2-furanyl)-2-(4-pyrimidinyl)is utilized as an intermediate in the synthesis of various pharmaceutical drugs. Its unique structure allows it to be a key component in the development of new medications, particularly those targeting specific medical conditions. Ethanone, 1-(2-furanyl)-2-(4-pyrimidinyl)-'s potential biological activity makes it a promising candidate for further research and development in the pharmaceutical sector.
Used in Agrochemical Industry:
In the agrochemical industry, Ethanone, 1-(2-furanyl)-2-(4-pyrimidinyl)is employed in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties enable it to be a valuable component in the formulation of these products, contributing to their effectiveness in controlling pests and weeds in agricultural settings.
Used in Organic Synthesis:
Due to its unique chemical structure, Ethanone, 1-(2-furanyl)-2-(4-pyrimidinyl)is also used as a building block in the synthesis of other organic compounds. Its versatility allows it to be incorporated into a wide range of chemical reactions, making it a valuable asset in the field of organic chemistry. This application further expands the potential uses of the compound across various industries.

InChI:InChI=1/C10H8N2O2/c13-9(10-2-1-5-14-10)6-8-3-4-11-7-12-8/h1-5,7H,6H2

Upstream product

• 3438-46-8 4-Methylpyrimidine 
• 614-99-3 Ethyl 2-furoate 

Downstream Products

• 851371-58-9 4'-(2-furyl)-4,5'-bipyrimidin-2'-amine 

Relevant articles and documents

Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A2B adenosine receptor antagonists

The synthesis and SAR of a series of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent A2B adenosine receptor antagonists is described. Several compounds showed good selectivity versus other adenosine receptors. The potent and selective analogue 9 was shown to have good oral bioavailability in the rat.

Discovery and characterization of 4′-(2-furyl)-N-pyridin-3-yl-4, 5′-bipyrimidin-2′-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist

A novel series of N-heteroaryl 4′-(2-furyl)-4,5′-bipyrimidin- 2′-amines has been identified as potent and selective A2B adenosine receptor antagonists. In particular, compound 5 showed high affinity for the A2B receptor (Ki = 17 nM), good selectivity (IC50: A1 > 1000 nM, A2A > 2500 nM, A3 > 1000 nM), displayed a favorable pharmacokinetic profile in preclinical species, and showed efficacy in functional in vitro models.

PYRIMIDIN-2-AMINE DERIVATES AND THEIR USE AS A2B ADENOSINE RECEPTOR ANTAGONISTS

This invention is directed to new potent and selective antagonists of the A2B adenosine receptor having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.