85153-83-9

Basic information

• Product Name: propyl 5-oxo-L-prolinate
• Synonyms: propyl 5-oxo-L-prolinate;(S)-5-Oxo-2-pyrrolidinecarboxylic acid propyl ester;5-Oxo-L-proline propyl ester;Einecs 285-868-0
• CAS NO: 85153-83-9
• Molecular Formula: C₈H₁₃NO₃
• Molecular Weight: 171.19372
• EINECS: 285-868-0
• Mol File: 85153-83-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 323 °C at 760 mmHg
• Flash Point: 149.2 °C
• Appearance: /
• Density: 1.127 g/cm³
• CAS DataBase Reference: propyl 5-oxo-L-prolinate(CAS DataBase Reference)
• NIST Chemistry Reference: propyl 5-oxo-L-prolinate(85153-83-9)
• EPA Substance Registry System: propyl 5-oxo-L-prolinate(85153-83-9)

Safety Data

• Hazardous Substances Data: 85153-83-9(Hazardous Substances Data)

Usage

General Description

Propyl 5-oxo-L-prolinate is a chemical compound with the molecular formula C8H15NO3. It is a derivative of the amino acid proline, and it is commonly used in the pharmaceutical and agricultural industries. propyl 5-oxo-L-prolinate has potential applications in the synthesis of pharmaceutical drugs and agrochemicals due to its unique chemical structure and properties. It may also have biological activities that make it useful for various medicinal and scientific purposes. Additionally, propyl 5-oxo-L-prolinate may have potential uses in organic chemistry as a building block for the synthesis of more complex molecules. Overall, propyl 5-oxo-L-prolinate is a versatile chemical compound with various practical applications in different fields.

Upstream product

• 71-23-8 propan-1-ol 
• 98-79-3 L-Pyroglutamic acid 

Relevant articles and documents

Synthesis and bioactivities evaluation of L-pyroglutamic acid analogues from natural product lead

A series of L-pyroglutamic acid analogues from natural product lead were designed and synthesized, as well as their antifungal activities against Phytophthora infestans, neuritogenic activities, antibacterial activities and anti-inflammatory activities are described. The bioassays and SAR study showed that the majority of L-pyroglutamic acid esters have a significant antifungal activity against P. infestans, especially 2d and 2j demonstrated the best activities with EC50 values of 1.44 and 1.21 μg mL?1, which were about seven times that of commercial azoxystrobin (7.85 μg mL?1). Moreover, compounds 2e, 2g and 4d displayed anti-inflammatory activity against LPS-induced NO production in BV-2 microglial cells; neuritogenic activity in NGF-induced PC-12 cells is the same activity. This study demonstrates that compounds 2d and 2j are potential drugs to control P. infestans.

Cosmetic composition containing DOPA derivatives

A composition for topical application to human hair or skin contains a chemical analogue of dihydroxyphenyl alanine (DOPA). This chemical analogue can be absorbed by skin or by a hair follicle and metabolised in-vivo, thus leading to the formation of melanin in skin or to the growth of melanin-pigmented hair. Consequently the composition can give controlled skin darkening to mimic sun-induced tanning or can bring about the growth of dar hair in place of the grey or white hair.

Cosmetic composition

A composition suitable for topical application to mammalian skin or hair for inducing, maintaining or increasing hair growth comprises: (i) a first chemical inhibitor chosen from proteoglycanase inhibitors, glycosaminoglycanase inhibitors, glycosaminoglycan chain cellular uptake inhibitors or mixtures thereof; and (ii) a cosmetically acceptable vehicle for the chemical inhibitor; provided that when the first chemical inhibitor is a weak inhibitor, such that a 1 mM aqueous solution of the inhibitor reduces proteoglycanase activity, glycosaminoglycanase activity or cellular uptake of glycosaminoglycan chains, by from 5 to 50%, in accordance with at least one of the assay tests as herein described, then there is also present in the composition a second chemical inhibitor and/or an activity enhancer. When minoxidil is the sole chemical inhibitor, then the activity enhancer is a penetration enhancer chosen from a limited number of materials, including certain esters and cationic polymers. The total amount of chemical inhibitor present in the composition is sufficient to increase hair growth in the rat, when said composition is applied topically thereto, by at least 10% more than that obtainable using a control composition from which the said inhibitors have been omitted.