851681-89-5 Usage
Uses
A potent and selective inhibitor of phosphodiesterase Type II (PDE2). It demonstrated no inhibition of 5-lipoxygenase (5-LO) or cyclooxygenase (COX-1) and is more potent and selective than EHNA (H825550).
Check Digit Verification of cas no
The CAS Registry Mumber 851681-89-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,1,6,8 and 1 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 851681-89:
(8*8)+(7*5)+(6*1)+(5*6)+(4*8)+(3*1)+(2*8)+(1*9)=195
195 % 10 = 5
So 851681-89-5 is a valid CAS Registry Number.
851681-89-5Relevant articles and documents
A new chemical tool for exploring the physiological function of the PDE2 isozyme
Chambers, Robert J.,Abrams, Kristin,Garceau, Norman Y.,Kamath, Ajith V.,Manley, Christopher M.,Lilley, Susan C.,Otte, Douglas A.,Scott, Dennis O.,Sheils, Alissa L.,Tess, David A.,Vellekoop, A. Samuel,Zhang, Yan,Lam, Kelvin T.
, p. 307 - 310 (2007/10/03)
Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.