851881-60-2 Usage
Description
ADX-47273 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5), exhibiting high selectivity and potency in enhancing glutamate activity. It demonstrates promising antipsychotic-like activity and cognitive-enhancing properties in preclinical models.
Used in Pharmaceutical Industry:
ADX-47273 is used as a potential therapeutic agent for the treatment of cognitive impairments and psychiatric disorders, such as schizophrenia, due to its ability to modulate mGluR5 activity, leading to improvements in recall, reduction in impulsivity, and enhanced reversal learning.
Used in Neuropharmacology Research:
ADX-47273 is used as a research tool for studying the role of mGluR5 in cognitive functions and the pathophysiology of psychiatric disorders. Its selectivity and potency make it a valuable compound for investigating the mechanisms underlying the therapeutic effects of mGluR5 modulation.
in vivo
adx47273 increased erk (extracellular signal-regulated kinase) and creb (camp-responsive element-binding protein) phosphorylation in rat hippocampus and prefrontal cortex. in rat and mouse models that sensitive to antipsychotic treatment, adx47273 decreased rat conditioned avoidance responding (minimal effective dose = 30 mg/kg i.p.) and reduced mouse ampomorphine-activated climbing (minimal effective dose = 100 mg/kg i.p.) [1]
references
[1] liu f, grauer s, kelley c, navarra r, graf r, zhang g, atkinson pj, popiolek m, wantuch c, khawaja x, smith d, olsen m, kouranova e, lai m, pruthi f, pulicicchio c, day m, gilbert a, pausch mh, brandon nj, beyer ce, comery ta, logue s, rosenzweig-lipson s, marquis kl. adx47273 [s-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and precognitive activities. j pharmacol exp ther. 2008 dec;327(3):827-39.
Check Digit Verification of cas no
The CAS Registry Mumber 851881-60-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,1,8,8 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 851881-60:
(8*8)+(7*5)+(6*1)+(5*8)+(4*8)+(3*1)+(2*6)+(1*0)=192
192 % 10 = 2
So 851881-60-2 is a valid CAS Registry Number.
851881-60-2Relevant articles and documents
ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
-
Page/Page column 56, (2008/06/13)
The present invention relates to new compounds of formula (I) wherein A, B, P, Q, W, Rl and R2 are defined in the description; invention compounds are useful in the prevention or treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.
