851895-22-2

Basic information

• Product Name: N,N-dimethyl-4-((trimethylsilyl)ethynyl) benzamide
• Synonyms: N,N-dimethyl-4-((trimethylsilyl)ethynyl) benzamide
• CAS NO: 851895-22-2
• Molecular Weight: 245.396
• Mol File: 851895-22-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-4-((trimethylsilyl)ethynyl) benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-4-((trimethylsilyl)ethynyl) benzamide(851895-22-2)
• EPA Substance Registry System: N,N-dimethyl-4-((trimethylsilyl)ethynyl) benzamide(851895-22-2)

Safety Data

• Hazardous Substances Data: 851895-22-2(Hazardous Substances Data)

Upstream product

• 24167-53-1 4-iodo-N,N-dimethylbenzamide 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 851895-23-3 4-(dimethylcarbamoyl)phenylacetylene 

Relevant articles and documents

Pd/Cu-Catalyzed Vinylation of Terminal Alkynes with (2-Bromoethyl)diphenylsulfonium Triflate

The potential of (2-bromoethyl)diphenylsulfonium triflate to be a powerful vinylation reagent was determined by the Sonogashira cross-coupling reactions with terminal alkynes. The vinylation proceeded smoothly at 25 °C under Pd/Cu catalysis to afford a variety of 1- and 2-unsubstituted 1,3-enynes in moderate to excellent yields. This protocol represents the first application of (2-haloethyl)diphenylsulfonium triflate as a CH═CH2 transfer source in organic synthesis.

BENZO [b][1,4] DIOXEPINE DERIVATIVES

This invention relates to compounds of the formula (I), wherein B, X, Y, Z, R1 and R2 are as defined in the description, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by ACCβ inhibitors.