851916-02-4

Basic information

• Product Name: benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid
• Synonyms: benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid
• CAS NO: 851916-02-4
• Molecular Weight: 456.116
• Mol File: 851916-02-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid(CAS DataBase Reference)
• NIST Chemistry Reference: benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid(851916-02-4)
• EPA Substance Registry System: benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid(851916-02-4)

Safety Data

• Hazardous Substances Data: 851916-02-4(Hazardous Substances Data)

Upstream product

• 1620164-64-8 octaethyl benzene-1,4-bis[aminomethylidene(bisphosphonate)] 
• 106-50-3 1,4-phenylenediamine 
• 6262-22-2 N-(4-formylaminophenyl)formamide 
• 935-16-0 1,4-phenylenediisocyanide 

Relevant articles and documents

Biological effects of aromatic bis[aminomethylidenebis(phosphonic)] acids in osteoclast precursors in vitro

Nitrogen-containing bisphosphonates (N-BPs) inhibit bone resorption by preventing osteoclast activity. Most clinically used BPs are hydroxybisphosphonates with the exception of incadronate, which belongs to the class of aminomethylidenebisphosphonic acids

Synthesis and antiproliferative activity of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids

A series of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids was synthesized in the reaction of triethylphosphite with isonitriles followed by hydrolysis or dealkylation. The in vitro anti-proliferative effect of all synthesized tetraphosphonic acids against MCF-7 breast cancer cells, J774E macrophages and HL-60 promyelocytic leukemia cells was determined. Three aromatic derivatives (5a, 5f and 5j) showed a similar or higher anti-proliferative activity than zoledronic acid.