852146-05-5

Basic information

• Product Name: 5-(2,3-dichlorophenyl)furan-2-carboxylic acid methyl ester
• Synonyms: 5-(2,3-dichlorophenyl)furan-2-carboxylic acid methyl ester
• CAS NO: 852146-05-5
• Molecular Weight: 271.1
• Mol File: 852146-05-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(2,3-dichlorophenyl)furan-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,3-dichlorophenyl)furan-2-carboxylic acid methyl ester(852146-05-5)
• EPA Substance Registry System: 5-(2,3-dichlorophenyl)furan-2-carboxylic acid methyl ester(852146-05-5)

Safety Data

• Hazardous Substances Data: 852146-05-5(Hazardous Substances Data)

Upstream product

• 2527-99-3 methyl 5-bromo-2-furoate 
• 151169-74-3 2,3-dichlorobenzeneboronic acid 

Relevant articles and documents

(5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1

A series of (5-arylfuran-2-ylcarbonyl)guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardiprotective efficacy against ischemia-reperfusion injury. Starting with (5-phenylfuran-2-ylcarbonyl) guanidine 47 with a moderate inhibitory effect on NHE-1, the compounds with various substituents at the phenyl ring were investigated with the aim to optimize the potency. In this study, the 2,5-disubstituted compounds appeared to have better activities than the other analogues, and the 2-methoxy-5- chlorophenyl compound 85 was found as a potent inhibitor of NHE-1 (IC 50 = 0.081 μM). Furthermore, 85 showed a marked reduction of infarct size in the rat myocardial infarction model in vivo and significant improvement of cardiac contractile function in the isolated rat heart ischemia model in vitro.