852204-45-6

Basic information

• Product Name: dimethyl (3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)phosphonate
• Synonyms: dimethyl (3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)phosphonate
• CAS NO: 852204-45-6
• Molecular Weight: 312.11
• Mol File: 852204-45-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: dimethyl (3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl (3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)phosphonate(852204-45-6)
• EPA Substance Registry System: dimethyl (3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)phosphonate(852204-45-6)

Safety Data

• Hazardous Substances Data: 852204-45-6(Hazardous Substances Data)

Upstream product

• 15104-44-6 dimethyl (3-chlorophenyl)phosphonate 
• 73183-34-3 bis(pinacol)diborane 
• 86364-03-6 3-chloro-1-trifluoromethanesulfonyloxybenzene 
• 108-43-0 3-monochlorophenol 
• 594823-67-3 (3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)bromobenzene) 
• 121-45-9 phosphorous acid trimethyl ester 
• 89598-96-9 (3-bromophenyl)boronic acid 
• 76-09-5 2,3-dimethyl-2,3-butane diol 

Relevant articles and documents

EZH2 INHIBITORS AND USES THEREOF

The present invention provides compound of formula 1, or an isotopic form, a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, a polymorph, a prodrug, S-oxide or N-oxide thereof. The invention also relates toprocesses for their preparation, to pharmaceutical compositions containing them and use of the compound of formula 1, in the treatment of diseases or disorders mediated by EZH2 (enhancer of zeste homolog 2), particularly cancer.

4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES

4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of a general formula (I) in which formula (II) represents an aryl or heteroaryl residue, Ar represents an aryl residue; U is a two to six atom chain; and the R’s represent substituents.