852283-23-9Relevant articles and documents
Hydrothiolation of benzyl mercaptan to arylacetylene: Application to the synthesis of (E) and (Z)-isomers of on 01910·Na (Rigosertib), a phase III clinical stage anti-cancer agent
Pallela, Venkat R.,Mallireddigari, Muralidhar R.,Cosenza, Stephen C.,Akula, Balaiah,Subbaiah, D. R. C. Venkata,Reddy, E. Premkumar,Reddy, M. V. Ramana
, p. 1964 - 1977 (2013/05/22)
A stereoselective and efficient method for free radical addition of benzyl thiol to aryl acetylene in the presence of Et3B-hexane has been developed for the synthesis of (Z) and (E)-styryl benzyl sulfides where base catalyzed hydrothiolations h
Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors
Chahrour, Osama,Abdalla, Ashraf,Lam, Frankie,Midgley, Carol,Wang, Shudong
, p. 3066 - 3069 (2011/06/24)
We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast.
