852329-47-6Relevant articles and documents
Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists
Zhang, Mingzhu,Tamiya, Junko,Nguyen, Linh,Rowbottom, Martin W.,Dyck, Brian,Vickers, Troy D.,Grey, Jonathan,Schwarz, David A.,Heise, Christopher E.,Haelewyn, Jason,Mistry, Monica S.,Goodfellow, Val S.
, p. 2535 - 2539 (2008/02/01)
A series of thienopyrimidinone bis-aminopyrrolidine ureas were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor-1. These compounds exhibit potent binding affinity (Ki = 3 nM) and good in vitro metabolic stability.