85264-36-4Relevant articles and documents
Copper(II) complexes containing N′-aromatic group substituted N,N′,N-bis((3,5-dimethyl-1H-pyrazol-1-yl)methyl)amines: Synthesis, structures, polymerization of methyl methacrylate and ring opening polymerization of rac-lactide
Cho, Hyungwoo,Choe, Solhye,Kim, Dongil,Lee, Hyosun,Nayab, Saira
, (2020)
A series of Cu(II) complexes, [LnCuCl2] (Ln = LA–LF), supported by N′-aromatic-group-substituted N,N-bis((3,5-dimethyl-1H-pyrazol-1-yl)methylamine ligands have been synthesized. Variations of substitu
X-ray crystal structures and MMA polymerization of cadmium(II) complexes with bidentate pyrazole ligands: The formation of monomers or dimers as a function of a methyl substituent on the pyrazole and aniline rings
Kim, Dongil,Kim, Sunghoon,Woo, Hyun Yul,Lee, Ha-Jin,Lee, Hyosun
, p. 445 - 453 (2014/06/09)
The reaction of CdBr2·4H2O with ancillary ligands, N,N-bis(1H-pyrazolyl-1-methyl)aniline (L1), N,N-bis(1H-pyrazolyl-1-methyl)-p-methylaniline (L2), N,N-bis(1H-pyrazolyl-1-methyl)-3,5-dimethylaniline (L3), N,N-bis(3,5-dimethyl-1H-pyrazolyl-1-methyl)aniline (L4) and N,N-bis(1H-pyrazolyl-1-methyl)-2,6-dimethylaniline (L5) in ethanol yields novel Cd(II) bromide complexes, [L1CdBr2] 2, [L2CdBr2]2, [L 3CdBr2]2, [L4CdBr2] and [L5CdBr2]. The X-ray crystal structures of [L 1CdBr2]2, [L2CdBr2] 2 and [L3CdBr2]2 reveal a bromo-bridged dimeric species with crystallographic inversion symmetry. Conversely, [L4CdBr2] and [L5CdBr2] exist as monomeric complexes, presumably due to the steric hindrance between the methyl substituents of the two pyrazole groups in the ligand and cadmium centre for [L4CdBr2], and crowding around the cadmium metal by methyl substituents on the aniline residue in the ligand for [L 5CdBr2]. The geometry at each Cd(II) centre for [L 1CdBr2]2, [L2CdBr2] 2 and [L3CdBr2]2 is best described as a distorted trigonal bipyramid. A distorted trigonal bipyramid is achieved in [L4CdBr2] by coordinative interaction of the nitrogen atom of the aniline unit and the cadmium atom with a σ plane of symmetry, based on the bond length of Cd-Naniline (2.759(7) A). [L 5CdBr2] exists with a distorted tetrahedral geometry involving non-coordination of the nitrogen atom of aniline and the Cd centre, resulting in the formation of an eight-membered chelate ring. The catalytic activity of monomeric, five-coordinated [L4CdBr2] in the polymerization of methyl methacrylate (MMA) in the presence of modified methylaluminoxane (MMAO) at 60°C resulted in a higher molecular weight and a narrower polydispersity index (PDI) than those obtained with dimeric [L nCdBr2]2 (Ln=L1, L 2, L3) or monomeric tetrahedral [L5CdBr 2]. Copyright
One pot synthesis and in vitro antitumor activity of some bipyrazolic tripodal derivatives
Radi, Smaail,Toubi, Yahya,Draoui, Nihed,Feron, Olivier,Riant, Olivier
experimental part, p. 305 - 309 (2012/06/18)
The synthesis and structure-activity relationships (SAR) antitumor activities of monopyrazolic and bipyrazolic tripodal derivatives are reported here for the first time. The ten products were tested against three human cancer cell lines including breast (MDA-MB231), prostate (PC3) and colorectal (LoVo) cancers. In bipyrazolic series, most of them exhibited a moderate antitumor activity against three human cancer cell lines with an order of 5 > 7 ≈ 8 in case of colorectal cancer and 5 > 7 > 8 in case of breast and prostate cancers.
