852812-44-3

Basic information

• Product Name: 4-benzyl-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester
• Synonyms: 4-benzyl-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester
• CAS NO: 852812-44-3
• Molecular Weight: 309.321
• Mol File: 852812-44-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-benzyl-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester(852812-44-3)
• EPA Substance Registry System: 4-benzyl-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester(852812-44-3)

Safety Data

• Hazardous Substances Data: 852812-44-3(Hazardous Substances Data)

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 620-86-0 4-Benzylbenzoic acid 

Relevant articles and documents

Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2

Excitatory amino acid transporters (EAATs) play a pivotal role in maintaining glutamate homeostasis in the mammalian central nervous system, with the EAAT-2 subtype thought to be responsible for the bulk of the glutamate uptake in forebrain regions. A complete elucidation of the functional role of EAAT-2 has been hampered by the lack of potent and selective pharmacological tools. In this study, we describe the synthesis and biological activities of novel aryl-ether, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of EAAT-2. Compound (16) represents one of the most potent (IC50 = 85 ± 5 nM) and selective inhibitors of EAAT-2 identified to date.