85290-78-4

Basic information

• Product Name: ethyl-3-methyl-1H-pyrazole-4-carboxylate
• Synonyms: ethyl-3-methyl-1H-pyrazole-4-carboxylate;Ethyl5-methylpyrazole-4-carboxylate;5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester;3-Methyl-1H-pyrazole-4-carboxylic Acid Ethyl Ester;NSC 19454;4-(Ethoxycarbonyl)-5-methyl-1H-pyrazole, Ethyl 3-methyl-1H-pyrazole-4-carboxylate, 4-(Ethoxycarbonyl)-3-methyl-1H-pyrazole;H-Pyrazole-4-carboxylicacid, 3-methyl-, ethyl ester;3-Methylpyrazole-4-carboxylate
• CAS NO: 85290-78-4
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.1665
• Product Categories: Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides
• Mol File: 85290-78-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 49-52°C
• Boiling Point: 280.6±20.0 °C(Predicted)
• Appearance: /
• Density: 1.171±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: 12.26±0.50(Predicted)
• CAS DataBase Reference: ethyl-3-methyl-1H-pyrazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl-3-methyl-1H-pyrazole-4-carboxylate(85290-78-4)
• EPA Substance Registry System: ethyl-3-methyl-1H-pyrazole-4-carboxylate(85290-78-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 85290-78-4(Hazardous Substances Data)

Usage

Description

Ethyl-3-methyl-1H-pyrazole-4-carboxylate is a yellow solid that exhibits systemic antifungal activity. Its chemical properties and structure contribute to its effectiveness in combating fungal infections.

Uses

Used in Agricultural Industry:
Ethyl-3-methyl-1H-pyrazole-4-carboxylate is used as a systemic antifungal agent for protecting crops from fungal infections. Its application helps maintain crop health and yield by reducing the impact of phytopathogenic fungi.
However, it is important to note that ethyl-3-methyl-1H-pyrazole-4-carboxylate also shows high levels of phytotoxicity, which may limit its application in certain agricultural contexts where the potential harm to plants must be carefully considered and managed.

Upstream product

• 49836-24-0 (E)-2-(ethoxymethylene)-3-oxobutanoic acid ethyl ester 
• 3724-43-4 Vilsmeier reagent 
• 141-97-9 ethyl acetoacetate 
• 64-17-5 ethanol 
• 40704-11-8 3-methyl-1H-pyrazole-4-carboxylic acid 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 134653-70-6 α-acetyl-α-(dimethylaminomethylene)acetic acid,ethyl ester 

Downstream Products

• 31728-75-3 1,5-dimethylpyrazole-4-carboxylic acid 
• 1307314-29-9 1-(2-cyano-6-fluoro-phenyl)-3-methyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 1307314-30-2 ethyl 1-[2-fluoro-6-(1-methyl-4,5-dihydroimidazol-2-yl)phenyl]-3-methyl-pyrazole-4-carboxylate 
• 1307314-31-3 ethyl 1-[2-fluoro-6-(1-methylimidazol-2-yl)phenyl]-3-methyl-pyrazole-4-carboxylate 
• 1307313-52-5 2-chloro-4,4-difluoro-1'-[[1-[2-fluoro-6-(1-methylimidazol-2-yl)phenyl]-3-methyl-pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine] 
• 1313195-84-4 N-(2-hydroxyethyl)-3-methyl-1-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1H-pyrazole-4-carboxamide 
• 1313196-05-2 5-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylic acid 
• 1313196-06-3 3-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboylic acid 
• 1313196-03-0 ethyl 5-methyl-1-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1Hpyrazole-4-carboxylate 
• 1313196-04-1 ethyl 3-methyl-1-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1H-pyrazole-4-carboxylate 
• 1307801-57-5 ethyl 1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carboxylate 
• 1307801-58-6 1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carboxylic acid 
• 1307801-59-7 (1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-3-methyl-1H-pyrazol-4-yl)methanol 
• 1307803-06-0 1-(2-(3,5-dimethylphenylamino)-5-fluoropyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carbaldehyde 

Relevant articles and documents

An efficient synthesis of 1-H-pyrazole-4-carboxylic acid esters with Vilsmeier reagent under neat conditions

A convenient, solvent-free Vilsmeier reagent is experimented under neat condition (both thermal and microwave conditions). An efficient method for the synthesis of various substituted 1H-pyrazole-4-carboxylic acid esters is reported.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Synthesis and antifungal activity of the derivatives of novel pyrazole carboxamide and isoxazolol pyrazole carboxylate

A series of pyrazole carboxamide and isoxazolol pyrazole carboxylate derivatives were designed and synthesized in this study. The structures of the compounds were elucidated based on spectral data (infrared, proton nuclear magnetic resonance and mass spectroscopy). Then, all of the compounds were bioassayed in vitro against four types of phytopathogenic fungi (Alternaria porri, Marssonina coronaria, Cercospora petroselini and Rhizoctonia solani ) using the mycelium growth inhibition method. The results showed that some of the synthesized pyrazole carboxamides displayed notable antifungal activity. The isoxazole pyrazole carboxylate 7ai exhibited significant antifungal activity against R. solani, with an EC50 value of 0.37 μg/mL. Nonetheless, this value was lower than that of the commercial fungicide, carbendazol.