85293-40-9

Basic information

• Product Name: (2E)-4-(2,5-dimethoxyphenyl)-4-oxobut-2-enoic acid
• CAS NO: 85293-40-9
• Molecular Formula: C₁₂H₁₂O₅
• Molecular Weight: 236.2207
• Mol File: 85293-40-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 447.2°C at 760 mmHg
• Flash Point: 175.1°C
• Density: 1.241g/cm³
• Vapor Pressure: 8.8E-09mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: (2E)-4-(2,5-dimethoxyphenyl)-4-oxobut-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-4-(2,5-dimethoxyphenyl)-4-oxobut-2-enoic acid(85293-40-9)
• EPA Substance Registry System: (2E)-4-(2,5-dimethoxyphenyl)-4-oxobut-2-enoic acid(85293-40-9)

Safety Data

• Hazardous Substances Data: 85293-40-9(Hazardous Substances Data)

Upstream product

• 108-31-6 maleic anhydride 
• 150-78-7 1,4-dimethoxybezene 
• 36680-28-1 (Z)-3-(ethoxycarbonyl)propenoyl chloride 
• 1201-38-3 2',5'-dimethoxyacetophenone 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 23349-26-0 (E)-methyl 4-(2,5-dimethoxyphenyl)-4-oxobut-2-enoate 

Relevant articles and documents

Design, synthesis, and bioevaluation of a novel class of (E)-4-oxo-crotonamide derivatives as potent antituberculosis agents

A series of novel (E)-4-oxo-2-crotonamide derivatives were designed and synthesized to find potent antituberculosis agents. All the target compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv(MTB). Results reveal that 4-phenyl moiety at part A and short methyl group at part C were found to be favorable. Most of the derivatives displayed promising activity against MTB with MIC ranging from 0.125 to 4 μg/mL. Especially, compound IIIa16 was found to have the best activity with MIC of 0.125 μg/mL against MTB and with MIC in the range of 0.05–0.48 μg/mL against drug-resistant clinical MTB isolates.

Gastro-protecting activity

Diseases and ailments accompanied by gastric and gastroduodenal lesions treated by administering a compound of the formula (I) STR1 in which R represents hydrogen or alkyl containing 1 to 5 carbon atoms and R1 and R2, identical or different, both represent alkoxy containing 1 to 3 carbon atoms, or both represent halogen, or R1 represents hydrogen and R2 represents halogen, nitro or trifluoromethyl, or R1 and R2 form a methylenedioxy group at adjacent carbon atoms, as well as pharmaceutically acceptable salts thereof, particularly alkali metal, alkaline earth metal, or amine salts of said acid.