853181-28-9

Basic information

• Product Name: methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate
• Synonyms: methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate
• CAS NO: 853181-28-9
• Molecular Weight: 330.402
• Mol File: 853181-28-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate(853181-28-9)
• EPA Substance Registry System: methyl 4-(4-fluorophenyl)-2-isopropyl-1,4,4a,5,6,7-hexahydro-[1,8]naphthyridine-3-carboxylate(853181-28-9)

Safety Data

• Hazardous Substances Data: 853181-28-9(Hazardous Substances Data)

Upstream product

• 853181-56-3 methyl 2-[(4-fluorophenyl)-(2-methoxy-3,4,5,6-tetrahydro-pyridin-3-yl)-methyl]-4-methyl-3-oxo-pentanoate 
• 853182-68-0 4-(4-fluorophenyl)-3-(1-oxo-2-methylpropyl)-3,4,4a,5,6,7-hexahydro-1,8-naphthyridin-2(1H)-one 
• 853182-65-7 methyl 4-(4-fluorophenyl)-4a,5,6,7-tetrahydro-2-(1-methylethyl)-4H-pyrano[2,3-b]pyridine-3-carboxylate 

Downstream Products

• 853181-57-4 methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-4,4a,5,6,7,8-hexahydro-[1,8]naphthyridine-3-carboxylate 
• 853181-27-8 methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate 
• 36340-89-3 N,N-diisopropylethylamine hydrochloride 

Relevant articles and documents

HMG-COA REDUCTASE INHIBITORS AND METHOD

Compounds are provided having the following structure (I) and pharmaceutically acceptable salts thereof, A is (II) or (III); wherein R1, R2, R3, R4, U, V, W, Y, and n are as defined above, which compounds are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia, dyslipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis as well as Alzheimer's disease and osteoporosis and may be employed as hormone replacement therapy. A method for treating the above diseases employing the above compounds is also provided.