853208-84-1Relevant articles and documents
Synthesis of chlorinated 2-(aminomethyl)- and 2-(alkoxymethyl)pyrroles
Verniest, Guido,Claessens, Sven,De Kimpe, Norbert
, p. 4631 - 4637 (2007/10/03)
The synthesis of chlorinated 2-(hydroxymethyl)-, 2-(alkoxymethyl)- and 2-(aminomethyl)pyrroles via aromatization of 2-aryl-3,3-dichloro-5-(bromomethyl) pyrrolines and via reduction of 2-formyl- and 2-cyanopyrroles is described. The former methodology also provided new 2-[(alkyl- or phenylamino)methyl]pyrroles and a 2-(phosphonomethyl)pyrrole. Halogenated and methylene-spaced functionalized pyrroles are of particular interest for their pronounced physiological activities.