853271-16-6

Basic information

• Product Name: 2-(2-broMo-5-fluorophenyl)propan-2-ol
• Synonyms: 2-(2-broMo-5-fluorophenyl)propan-2-ol
• CAS NO: 853271-16-6
• Molecular Weight: 233.08
• Mol File: 853271-16-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2-broMo-5-fluorophenyl)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-broMo-5-fluorophenyl)propan-2-ol(853271-16-6)
• EPA Substance Registry System: 2-(2-broMo-5-fluorophenyl)propan-2-ol(853271-16-6)

Safety Data

• Hazardous Substances Data: 853271-16-6(Hazardous Substances Data)

Usage

General Description

2-(2-bromo-5-fluorophenyl)propan-2-ol, also known as BFP, is a chemical compound that belongs to the class of alcohols. It is a secondary alcohol with a molecular formula of C9H10BrFO and a molecular weight of 233.08 g/mol. BFP is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also utilized as an intermediate in the production of fine chemicals and as a reagent in organic synthesis. Additionally, BFP has potential applications in the field of medicinal chemistry, particularly in the development of new therapeutic compounds. However, it is important to handle this chemical with caution and in accordance with safety guidelines, as it may pose health and environmental risks if not properly managed.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 6942-39-8 methyl 2-bromo-5-fluorobenzoate 
• 394-28-5 2-Bromo-5-fluorobenzoic acid 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1254981-98-0 1-benzyl-4-[4-fluoro-2-(1-hydroxy-1-methyl-ethyl)-phenyl]-4-hydroxypiperidine 
• 853270-98-1 4-fluoro-2-(1-methoxy-1-methylethyl)-1-vinylbenzene 
• 853271-20-2 4-fluoro-2-(1-methoxy-1-methylethyl)benzaldehyde 
• 853271-18-8 1-bromo-4-fluoro-2-(1-methoxy-1-methylethyl)benzene 

Relevant articles and documents

Benzoxaborole Catalyst for Site-Selective Modification of Polyols

The site-selective modification of polyols bearing several hydroxyl groups without the use of protecting groups remains a significant challenge in synthetic chemistry. To address this problem, novel benzoxaborole derivatives were designed as efficient catalysts for the highly site-selective and protecting-group-free modification of polyols. To identify the effective substituent groups enhancing the catalytic activity and selectivity, a series of benzoxaborole catalysts 1a–k were synthesized. In-depth analysis for the substituent effect revealed that 1i–k, bearing multiple electron-withdrawing fluoro- and trifluoromethyl groups, exhibited the greatest catalytic activity and selectivity. Moreover, 1i-catalyzed benzoylation, tosylation, benzylation, and glycosylation of various cis-1,2-diol derivatives proceeded with good yield and site-selective manner.

Zirconocene-mediated and/or catalyzed unprecedented coupling reactions of alkoxymethyl-substituted styrene derivatives

Reactions of o-(alkoxymethyl)styrene derivatives with a stoichiometric amount of zirconocenebutene complex (zirconocene equivalent, "Cp 2Zr") brought about an insertion of the zirconocene species into a benzylic carbon-oxygen bond. The oxidative insertion of Cp2Zr to the benzylic carbon-oxygen bond is a result of sequential reactions: (i) formation of zirconacyclopropane by the ligand exchange with o-(alkoxymethyl)styrene, (ii) elimination of the alkoxy group through an aromatic conjugate system giving metalated o-quinodimethane species, and (iii) transfer of zirconium metal to the benzylic position. Through use of a catalytic amount of "Cp2Zr", however, unprecedented homo-coupling reactions (dimerization) of o-(alkoxymethyl)styrene derivatives occurred to give a tetracyclic compound. On the other hand, reactions of o-(1-alkoxyisopropyl) styrene derivatives gave rise to the analogous tetracyclic compounds regardless of the amount of "Cp2Zr" (stoichiometric or catalytic). Heterocoupling product between o-(1-alkoxyisopropyl)styrene and styrene congeners was obtained in high cis stereo- and regioselectivity by treating o-(1-alkoxyisopropyl)styrene derivatives with "Cp2Zr" in the presence of an excess amount of styrene derivatives.