853655-44-4 Usage
Functional groups
Ketone, benzene ring, bromomethyl group, methoxy group
Structure
Contains a benzene ring with a bromomethyl group and a methoxy group attached to it
Applications
Used in organic synthesis as a building block for various pharmaceuticals and agrochemicals
Intermediate
Used in the production of dyes, fragrances, and other specialty chemicals
Reactivity
Bromomethyl group can undergo various reactions for further functionalization
Versatility
Valuable in chemical synthesis due to its ability to undergo different reactions
Importance in medicinal chemistry
Distinctive aromatic and functional groups make it valuable for structure-activity relationship studies
Check Digit Verification of cas no
The CAS Registry Mumber 853655-44-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,3,6,5 and 5 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 853655-44:
(8*8)+(7*5)+(6*3)+(5*6)+(4*5)+(3*5)+(2*4)+(1*4)=194
194 % 10 = 4
So 853655-44-4 is a valid CAS Registry Number.
853655-44-4Relevant articles and documents
Azido-containing aryl β-diketo acid HIV-1 integrase inhibitors
Zhang, Xuechun,Pais, Godwin C.G.,Svarovskaia, Evguenia S.,Marchand, Christophe,Johnson, Allison A.,Karki, Rajeshri G.,Nicklaus, Marc C.,Pathak, Vinay K.,Pommier, Yves,Burke Jr., Terrence R.
, p. 1215 - 1219 (2003)
Aryl β-diketo acids (ADK) comprise a general class of potent HIV-1 integrase (IN) inhibitors, which can exhibit selective inhibition of strand transfer reactions in extracellular recombinant IN assays and provide potent antiviral effects in HIV-infected cells. Recent studies have shown that polycyclic aryl or aryl rings bearing aryl-containing substituents are components of potent members of this class. Reported herein is the first use of azido functionality as an aryl replacement in β-diketo acid IN inhibitors. The ability of azido-containing inhibitors to exhibit potent inhibition of IN and antiviral protection in HIV-infected cells, renders the azide group of potential value in the further development of ADK-based IN inhibitors.
