85375-15-1 Usage
Uses
SKF-89976A is a GABA transporters (GATs) type 1 inhibitor.
Biological Activity
A potent GABA uptake inhibitor, selective for GAT-1 (IC 50 values are 0.13, 550, 944 and 7210 μ M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (K i = 7 μ M) and transmitter-gated current non-competitively (K i = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 85375-15-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,3,7 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 85375-15:
(7*8)+(6*5)+(5*3)+(4*7)+(3*5)+(2*1)+(1*5)=151
151 % 10 = 1
So 85375-15-1 is a valid CAS Registry Number.
InChI:InChI=1/C22H25NO2.ClH/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19;/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25);1H
85375-15-1Relevant articles and documents
Orally Active and Potent Inhibitors of γ-Aminobutyric Acid Uptake
Ali, Fadia E.,Bondinell, William E.,Dandridge, Penelope A.,Frazee, James S.,Garvey, Eleanor,et al.
, p. 653 - 660 (2007/10/02)
3-Pyrrolidineacetic acid (1a), certain piperidinecarboxylic acids - i.e., piperidinecarboxylic acid (2a), 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid (3a), and cis-4-hydroxy-3-piperidinecarboxylic acid (4a) - cis-3-aminocyclohexanecarboxylic acid (5a, ci
