853893-95-5

Basic information

• Product Name: (2S)-N-{(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropyl}-3-methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanamide
• Synonyms: (2S)-N-{(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropyl}-3-methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanamide
• CAS NO: 853893-95-5
• Molecular Weight: 670.897
• Mol File: 853893-95-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-N-{(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropyl}-3-methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-N-{(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropyl}-3-methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanamide(853893-95-5)
• EPA Substance Registry System: (2S)-N-{(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropyl}-3-methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanamide(853893-95-5)

Safety Data

• Hazardous Substances Data: 853893-95-5(Hazardous Substances Data)

Upstream product

• 853893-93-3 (2S)-3-methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxoimidazolidin-1-yl}butanoic Acid 
• 169280-56-2 4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide 
• 853894-11-8 tert-butyl (2-hydroxyethyl)[(2-methyl-1,3-thiazol-4-yl)methyl]carbamate 
• 853894-12-9 Methyl (2S)-3-methyl-2-[(2-{[(2-methyl-1,3-thiazol-4-yl)methyl]amino}ethyl)amino]butanoate 
• 853894-15-2 (S)-3-Methyl-2-[3-(2-methyl-thiazol-4-ylmethyl)-2-oxo-imidazolidin-1-yl]-butyric acid methyl ester 
• 191226-98-9 [(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester 
• 853894-13-0 2-{[(2-methyl-1,3-thiazol-4-yl)methyl]amino}ethanol 
• 183004-94-6 3-S-(N-tert-butyloxyformamido)-[2R-hydroxy-1-[(4-aminophenylsulfonyl)(2-methylpropyl)]amino]-4-phenylbutane 
• 98760-08-8 (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester 
• 39238-07-8 4-(chloromethyl)-2-methyl-1,3-thiazole 
• 853894-14-1 2-{2-[tert-butoxycarbonyl-(2-methyl-thiazol-4-ylmethyl)-amino]-ethylamino}-3-methyl-butyric acid methyl ester 

Relevant articles and documents

Oximinoarylsulfonamides as potent HIV protease inhibitors

The need for a potent HIV protease inhibitor (PI) to combat emerging PI-resistant viruses is anticipated. Analogs formulated from the combination of structural fragments of Ritonavir, Lopinavir, and Amprenavir were synthesized. Analogs containing the oxime pharmacophore were found to have improved activities against both wild type and resistant (A17) viruses. The synthesis and structure-activity relationships (SAR) based upon the in vitro IC50 of this series of compounds are reported.