854001-41-5

Basic information

• Product Name: (S)-2-((1S,3R,5S)-3,5-Dimethyl-cyclohexyloxycarbonylamino)-hexanoic acid
• CAS NO: 854001-41-5
• Molecular Weight: 285.384
• Mol File: 854001-41-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-((1S,3R,5S)-3,5-Dimethyl-cyclohexyloxycarbonylamino)-hexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((1S,3R,5S)-3,5-Dimethyl-cyclohexyloxycarbonylamino)-hexanoic acid(854001-41-5)
• EPA Substance Registry System: (S)-2-((1S,3R,5S)-3,5-Dimethyl-cyclohexyloxycarbonylamino)-hexanoic acid(854001-41-5)

Safety Data

• Hazardous Substances Data: 854001-41-5(Hazardous Substances Data)

Upstream product

• 96789-62-7 (S)-2-Isocyanato-hexanoic acid methyl ester 
• 767-13-5 3,5-dimethylcyclohexanol 
• 907561-63-1 (S)-2-((1S,3R,5S)-3,5-Dimethyl-cyclohexyloxycarbonylamino)-hexanoic acid methyl ester 

Downstream Products

• 854001-45-9 {(S)-1-[2-Cyano-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-pentyl}-carbamic acid (1S,3R,5S)-3,5-dimethyl-cyclohexyl ester 

Relevant articles and documents

A structural screening approach to ketoamide-based inhibitors of cathepsin K

Several novel ketoamide-based inhibitors of cathepsin K have been identified. Starting from a modestly potent inhibitor, structural screening of P2 elements led to 100-fold enhancements in inhibitory activity. Modifications to one of these leads resulted in an orally bioavailable cathepsin K inhibitor.