85491-26-5

Basic information

• Product Name: (chloromethyl)bis(4-fluorophenyl)methylsilane
• Synonyms: (chloromethyl)bis(4-fluorophenyl)methylsilane;Bis(4-fluorophenyl)methyl(chloromethyl)silane
• CAS NO: 85491-26-5
• Molecular Formula: C₁₄H₁₃ClF₂Si
• Molecular Weight: 282.79
• EINECS: 401-200-4
• Mol File: 85491-26-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 107℃ (0.001 Torr)
• Flash Point: 130.249°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: (chloromethyl)bis(4-fluorophenyl)methylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: (chloromethyl)bis(4-fluorophenyl)methylsilane(85491-26-5)
• EPA Substance Registry System: (chloromethyl)bis(4-fluorophenyl)methylsilane(85491-26-5)

Safety Data

• Hazard Codes: N
• Statements: 51/53
• Safety Statements: 61
• Hazardous Substances Data: 85491-26-5(Hazardous Substances Data)

Usage

General Description

(Chloromethyl)bis(4-fluorophenyl)methylsilane is a chemical compound with the formula C9H10ClFSi. It is a silane compound that contains a silicon atom bonded to two methyl groups, a chloromethyl group, and two 4-fluorophenyl groups. (chloromethyl)bis(4-fluorophenyl)methylsilane is used in organic synthesis as a versatile building block for creating complex molecules. It can be used as a potential reagent for the preparation of various silanes and organosilicon compounds, as well as a precursor for the synthesis of pharmaceuticals and agrochemicals. Additionally, (Chloromethyl)bis(4-fluorophenyl)methylsilane may find applications in materials science and as a starting material for the production of functionalized silicones.

InChI:InChI=1/C14H13ClF2Si/c1-18(10-15,13-6-2-11(16)3-7-13)14-8-4-12(17)5-9-14/h2-9H,10H2,1H3

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 1558-33-4 chloromethylmethyldichlorosilane 

Downstream Products

• 85509-19-9 Flusilazole 

Relevant articles and documents

Flusilazole and synthesis method thereof

The invention discloses flusilazole and a synthesis method thereof. The synthesis method comprises the following steps: putting magnesium powder into a Grignard reaction kettle; adding an organic solvent and uniformly stirring; cooling and adding p-fluorobromobenzene in one step; mixing and stirring; dropwise adding the p-fluorobromobenzene, and keeping heat and reacting; cooling and storing to obtain a p-fluorobromobenzene Grignard reagent; raising the temperature of the p-fluorobromobenzene Grignard reagent; dropwise adding methyl chloromethyl dichlorosilane and carrying out heat insulation;recycling an organic solvent under negative pressure to obtain a flusilazole intermediate, magnesium bromide and magnesium chloride; adding DMF (Dimethyl Formamide), stirring, cooling and centrifuging; removing the magnesium bromide and the magnesium chloride to obtain a DMF mother solution; dissolving triazole sodium salt into formamide; adding the DMF mother solution and reacting; recycling theDMF under negative pressure and distilling in vacuum; cooling to obtain the flusilazole. The content of the flusilazole is greater than or equal to 95.0 percent and the yield is 80 to 90 percent; thesynthesis method has the advantages of moderate reaction conditions, safety in operation, low equipment requirements, low cost, no wastewater and easiness for operation and implementation, and is suitable for large-scale production of enterprises.