855-31-2

Basic information

• Product Name: 1H-Pyrrole, 1-(4-methoxyphenyl)-2,5-diphenyl-
• Synonyms: 1-(4-methoxyphenyl)-2,5-diphenylpyrrole;1-(4-Methoxy-phenyl)-2,5-diphenyl-pyrrol;1-(p-methoxyphenyl)-2,5-diphenylpyrrole
• CAS NO: 855-31-2
• Molecular Formula: C23H19NO
• Molecular Weight: 325.41
• Mol File: 855-31-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole, 1-(4-methoxyphenyl)-2,5-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole, 1-(4-methoxyphenyl)-2,5-diphenyl-(855-31-2)
• EPA Substance Registry System: 1H-Pyrrole, 1-(4-methoxyphenyl)-2,5-diphenyl-(855-31-2)

Safety Data

• Hazardous Substances Data: 855-31-2(Hazardous Substances Data)

Usage

Heterocyclic compound

A compound that contains a five-membered ring with four carbon atoms and one nitrogen atom.

Contains phenyl and 4-methoxyphenyl groups

The presence of these groups makes the compound important for pharmaceutical and chemical applications.

Potential biological activities

The compound has been studied for its potential medicinal properties and is used in research for the development of new drugs and pharmaceuticals.

Valuable building block for synthesizing complex organic molecules

The unique chemical structure of the compound makes it useful for creating complex organic molecules.

Upstream product

• 72867-36-8 (N-benzoyl-p-anisidino)-phenyl-acetonitrile 
• 5044-52-0 vinyltriphenylphosphonium bromide 
• 536-74-3 phenylacetylene 
• 886-66-8 1,4-diphenyl-1,3-butadiyne 
• 104-94-9 4-methoxy-aniline 
• 98-86-2 acetophenone 
• 2743-00-2 (E)-4-methoxy-N-(1-phenylethylidene)benzenamine 
• 495-71-6 phenacylacetophenone 

Downstream Products

• 188483-20-7 5-benzoyl-3-phenylisothiazole 
• 853-38-3 1-(4-hydroxyphenyl)-2,5-diphenyl-1H-pyrrole 
• 877-68-9 4-trimethylsilylanisole 
• 13132-25-7 4-(trimethylsilyl)phenol 
• 1456622-60-8 1,1'-bis(4-methoxyphenyl)-2,2',5,5'-tetraphenyl-3,3'-bipyrrole 

Relevant articles and documents

Generation of Aryllithium Reagents from N -Arylpyrroles Using Lithium

Treatment of 1-aryl-2,5-diphenylpyrroles with lithium powder in tetrahydrofuran at 0 °C results in the generation of the corresponding aryllithium reagents through reductive C-N bond cleavage.

A general approach to arylated furans, pyrroles, and thiophenes

A general and practical synthetic method for aryl-substituted five-membered heterocycles has been developed. In the presence of KOH (30%), 1,4-diaryl-1,3-butadiynes undergo the cyclocondensation reaction with water, primary amines, and Na2S·9H2O in DMSO at 80 °C to afford 2,5-diarylfurans, 1,2,5-trisubstituted pyrroles, and 2,5-diarylthiophenes in good to high yields. Further studies have disclosed that aryl-substituted five-membered heterocycles can be also synthesized by a one-pot, two-step strategy from the terminal alkynes in DMSO firstly catalyzed by CuCl, and then via addition of KOH to promote the cyclocondensation of 1,3-butadiynes generated in situ.

CuCl-catalyzed cycloaddition of 1,3-butadiynes with primary amines: An atom-economic process for synthesis of 1,2,5-trisubsituted pyrroles

1,3-Butadiynes underwent inter- and intramolecular double hydroamination with primary amines in the presence of CuCl at 100°C to afford 1,2,5-trisubsituted pyrroles in good to high yields.