855231-06-0

Basic information

• Product Name: 4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid
• Synonyms: 4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid
• CAS NO: 855231-06-0
• Molecular Weight: 351.377
• Mol File: 855231-06-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid(855231-06-0)
• EPA Substance Registry System: 4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid(855231-06-0)

Safety Data

• Hazardous Substances Data: 855231-06-0(Hazardous Substances Data)

Upstream product

• 459-04-1 4-Fluorophenylacetyl chloride 
• 71-43-2 benzene 
• 347-91-1 2-(4-fluorophenyl)-1-phenylethanone 
• 3183-22-0 ethyl 2-(isopropylamino)acetate 
• 855231-00-4 4-(4-fluorophenyl)-3-phenyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 855231-02-6 4-(4-fluoro-phenyl)-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 855231-04-8 4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid ethyl ester 

Downstream Products

• 1027039-32-2 C₂₁H₁₇ClFNO₂ 
• 855249-00-2 4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-methoxybenzylamide 
• 950599-15-2 C₄₂H₄₈FN₃O₅Si 
• 950599-17-4 C₄₂H₅₀FN₃O₆Si 
• 950599-19-6 C₄₄H₅₄FN₃O₆Si 
• 950599-21-0 C₄₂H₄₉FN₂O₇Si 
• 950599-24-3 C₃₉H₄₈FN₃O₅SSi 
• 950599-26-5 C₄₀H₄₈FN₃O₅Si 
• 950599-27-6 C₄₀H₅₁FN₄O₅Si 
• 950599-29-8 C₃₉H₄₉FN₄O₅Si 
• 950599-31-2 C₃₉H₄₉FN₄O₅Si 
• 950599-33-4 C₃₄H₄₃FN₂O₅Si 
• 950599-35-6 C₃₅H₄₅FN₂O₅Si 
• 950599-37-8 C₃₆H₄₇FN₂O₅Si 

Relevant articles and documents

Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors

This paper describes the development of an efficient and scalable second generation synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors. Compound 1 was identified as part of a discovery program aimed at finding improved treatments for hypercholesterolemia. Herein, we describe an efficient synthesis of its highly functionalized pyrrole core followed by attachment of the 3,5-dihydroxyhexanoic acid side chain via ylide olefination chemistry.

N-ALKYL PYRROLES AS HMG-COA REDUCTASE INHIBITORS

HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided. Formula (I).