855238-75-4

Basic information

• Product Name: 1,2-bis-(4-methoxy-phenyl)-1-phenyl-butan-1-ol
• Synonyms: 1,2-bis-(4-methoxy-phenyl)-1-phenyl-butan-1-ol
• CAS NO: 855238-75-4
• Molecular Weight: 362.469
• Mol File: 855238-75-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,2-bis-(4-methoxy-phenyl)-1-phenyl-butan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-bis-(4-methoxy-phenyl)-1-phenyl-butan-1-ol(855238-75-4)
• EPA Substance Registry System: 1,2-bis-(4-methoxy-phenyl)-1-phenyl-butan-1-ol(855238-75-4)

Safety Data

• Hazardous Substances Data: 855238-75-4(Hazardous Substances Data)

Upstream product

• 4390-94-7 1,2-bis(4-methoxyphenyl)butanone 
• 108-86-1 bromobenzene 
• 120-44-5 1,4-di(4-methoxyphenyl)ethanone 

Downstream Products

• 13732-58-6 (E)-4,4'-(1-phenylbut-1-ene-1,2-diyl)bis(methoxybenzene) 
• 4120-45-0 E-4-(1-(4-hydroxyphenyl)-1-phenylbut-1-en-2-yl)phenol 
• 82333-73-1 Acetic acid 4-[(E)-2-(4-acetoxy-phenyl)-1-phenyl-but-1-enyl]-phenyl ester 
• 13867-30-6 (Z)-4,4'-(1-phenylbut-1-ene-1,2-diyl)bis(methoxybenzene) 

Relevant articles and documents

Structure-function relationships of estrogenic triphenylethylenes related to endoxifen and 4-hydroxytamoxifen

Estrogens can potentially be classified into planar (class I) or nonplanar (class II) categories, which might have biological consequences. 1,1,2-Triphenylethylene (TPE) derivatives were synthesized and evaluated against 17β-estradiol (E2) for their estrogenic activity in MCF-7 human breast cancer cells. All TPEs were estrogenic and, unlike 4-hydroxytamoxifen (4OHTAM) and Endoxifen, induced cell growth to a level comparable to that of E2. All the TPEs increased ERE activity in MCF-7:WS8 cells with the order of potency as followed: E2 > 1,1-bis(4,4′-hydroxyphenyl)-2-phenylbut-1-ene (15) > 1,1,2-tris(4-hydroxyphenyl)but-1-ene (3) > Z 4-(1-(4-hydroxyphenyl)-1- phenylbut-1-en-2-yl)phenol (7) > E 4-(1-(4-hydroxyphenyl)-1-phenylbut-1-en-2- yl)phenol (6) > Z(4-(1-(4-ethoxyphenyl)-1-(4-hydroxyphenyl)but-1-en-2-yl) phenol (12) > 4-OHTAM. Transient transfection of the ER-negative breast cancer cell line T47D:C4:2 with wild-type ER or D351G ER mutant revealed that all of the TPEs increased ERE activity in the cells expressing the wild-type ER but not the mutant, thus confirming the importance of Asp351 for ER activation by the TPEs. The findings confirm E2 as a class I estrogen and the TPEs as class II estrogens. Using available conformations of the ER liganded with 4OHTAM or diethylstilbestrol, the TPEs optimally occupy the 4OHTAM ER conformation that expresses Asp351.