855300-09-3

Basic information

• Product Name: 3'-(ethyl(Methyl)carbaMoyl)oxyacetophenone
• Synonyms: 3'-(ethyl(Methyl)carbaMoyl)oxyacetophenone;CarbaMic acid, ethylMethyl-, 3-acetylphenyl ester;N-Ethyl-N-methylcarbamic acid 3-acetylphenyl ester;3-Acetylphenyl ethyl(Methyl)-carbaMate;RivastigMine USP RC D;Des [3-(1-DiMethylaMino)ethyl] 3-Acetyl RivastigMine;RivastigMine Related CoMpound D;Rivastigmine EP Impurity C
• CAS NO: 855300-09-3
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.2524
• Mol File: 855300-09-3.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 337℃
• Flash Point: 158℃
• Appearance: /
• Density: 1.112
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Chloroform (Slightly)
• PKA: -1.56±0.70(Predicted)
• CAS DataBase Reference: 3'-(ethyl(Methyl)carbaMoyl)oxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-(ethyl(Methyl)carbaMoyl)oxyacetophenone(855300-09-3)
• EPA Substance Registry System: 3'-(ethyl(Methyl)carbaMoyl)oxyacetophenone(855300-09-3)

Safety Data

• Hazardous Substances Data: 855300-09-3(Hazardous Substances Data)

Usage

Description

3'-(ethyl(Methyl)carbaMoyl)oxyacetophenone is a chemical compound that features a unique structure with an ethyl(methyl)carbamoyl group attached to an acetophenone moiety. This molecule is characterized by its potential reactivity and functional group versatility, which can be exploited in various chemical and pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
3'-(ethyl(Methyl)carbaMoyl)oxyacetophenone is used as an intermediate in the synthesis of various pharmaceutical compounds for its ability to be modified and incorporated into complex molecular structures. Its carbamoyl group can be utilized to form amide linkages, which are common in drug molecules, enhancing the compound's potential as a building block in medicinal chemistry.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3'-(ethyl(Methyl)carbaMoyl)oxyacetophenone is used as a versatile reactant for the preparation of a wide range of organic compounds. Its reactivity allows for the formation of various derivatives, making it a valuable precursor in the synthesis of specialty chemicals, agrochemicals, and other fine chemicals.
Used in Research and Development:
3'-(ethyl(Methyl)carbaMoyl)oxyacetophenone is also used in research and development settings as a probe for studying the reactivity and selectivity of various chemical reactions. Its unique structure can provide insights into reaction mechanisms and help optimize synthetic routes for the production of target molecules.

Upstream product

• 42252-34-6 N-ethyl-N-methylcarbamoyl chloride 
• 121-71-1 3-Hydroxyacetophenone 
• 123441-03-2 rivastigmin 

Downstream Products

• 105601-20-5 rac-rivastigmine 
• 856408-80-5 (R)-N-ethyl-N-methylcarbamic acid-3-(1-hydroxyethyl)phenyl ester 
• 1222073-98-4 rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene 
• 1257519-35-9 (S)-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene 
• 1222073-99-5 (R)-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-acetoxyethyl) benzene 
• 1361513-76-9 1-(3-((ethyl(methyl)carbamoyl)oxy)phenyl)vinyl acetate 
• 1176026-49-5 (S)-3-(1-aminoethyl)phenyl ethyl(methyl)carbamate 
• 123441-03-2 rivastigmin 
• 1418318-99-6 C₁₃H₁₉NO₅S 
• 1346602-84-3 3-vinylphenyl N-ethyl-N-methylcarbamate 
• 186507-11-9 (2E)-1-(3-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 

Relevant articles and documents

Synthesis method of rivastigmine optical isomerization intermediate and (R)-rivastigmine

The invention provides a synthesis method of a rivastigmine optical isomerization intermediate and (R)-rivastigmine. The method comprises the following steps: carrying out an asymmetric reductive amination reaction on 3-nitromethyl ethyl formate acetophen

A method for preparing Rivastigmine citrate (by machine translation)

The invention discloses a method for preparing Rivastigmine citrate, said method is to meta-hydroxy acetophenone, methyl ethyl carbamic chloride as the raw material in the isotope energy level transitions, alternately high and low frequency ultrasonic and

A General Catalytic Method for Highly Cost- and Atom-Efficient Nucleophilic Substitutions

A general formamide-catalyzed protocol for the efficient transformation of alcohols into alkyl chlorides, which is promoted by substoichiometric amounts (down to 34 mol %) of inexpensive trichlorotriazine (TCT), is introduced. This is the first example of a TCT-mediated dihydroxychlorination of an OH-containing substrate (e.g., alcohols and carboxylic acids) in which all three chlorine atoms of TCT are transferred to the starting material. The consequently enhanced atom economy facilitates a significantly improved waste balance (E-factors down to 4), cost efficiency, and scalability (>50 g). Furthermore, the current procedure is distinguished by high levels of functional-group compatibility and stereoselectivity, as only weakly acidic cyanuric acid is released as exclusive byproduct. Finally, a one-pot protocol for the preparation of amines, azides, ethers, and sulfides enabled the synthesis of the drug rivastigmine with twofold SN2 inversion, which demonstrates the high practical value of the presented method.