85539-59-9

Basic information

• Product Name: 1-Benzyl-4-iodomethyl-pyrrolidin-2-one
• Synonyms: 1-Benzyl-4-iodomethyl-pyrrolidin-2-one
• CAS NO: 85539-59-9
• Molecular Weight: 315.154
• Mol File: 85539-59-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-Benzyl-4-iodomethyl-pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-4-iodomethyl-pyrrolidin-2-one(85539-59-9)
• EPA Substance Registry System: 1-Benzyl-4-iodomethyl-pyrrolidin-2-one(85539-59-9)

Safety Data

• Hazardous Substances Data: 85539-59-9(Hazardous Substances Data)

Upstream product

• 85539-55-5 N-allyl-N-benzyl-2-iodoacetamide 
• 288-32-4 1H-imidazole 
• 96449-69-3 1-benzyl-4-(hydroxymethyl)-2-pyrrolidinone 

Relevant articles and documents

Alpha2delta ligands for fibromyalgia and other disorders

This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; and R2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S, 5R)-3-Aminomethyl-5-methyl-octanoic acid

Mono-and disubstituted 3-propyl gamma-aminobutyric acids

The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I 1The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.

Triethylborane-mediated atom-transfer cyclisation of 2-iodo-N-(prop-2-enyl)acetamides and related compounds

The 2-iodo-N-(prop-2-enyl)acetamides 1, upon treatment with triethylborane (0.2-0.6 mol equiv.) in boiling benzene, undergo iodine atom-transfer cyclisation to give the 4-(iodomethyl)pyrrolidin-2-ones 2 in high yields. The method has been applied to the synthesis of γ-lactones.