855403-42-8

Basic information

• Product Name: 3-CHLORO-4-IODOPHENOL
• Synonyms: 3-CHLORO-4-IODOPHENOL;Phenol, 3-chloro-4-iodo-
• CAS NO: 855403-42-8
• Molecular Formula: C₆H₄ClIO
• Molecular Weight: 254.45283
• Mol File: 855403-42-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 40 °C
• Boiling Point: 296.9±25.0 °C(Predicted)
• Appearance: /
• Density: 2.087±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.39±0.18(Predicted)
• CAS DataBase Reference: 3-CHLORO-4-IODOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-IODOPHENOL(855403-42-8)
• EPA Substance Registry System: 3-CHLORO-4-IODOPHENOL(855403-42-8)

Safety Data

• Hazardous Substances Data: 855403-42-8(Hazardous Substances Data)

Usage

General Description

3-Chloro-4-iodophenol is a chemical compound with the molecular formula C6H4ClIO. It is a derivative of phenol that contains both a chlorine and an iodine atom in the para position to the hydroxyl group. 3-CHLORO-4-IODOPHENOL is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a reagent in organic chemistry reactions, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. 3-Chloro-4-iodophenol is classified as a hazardous substance and should be handled and stored according to proper safety guidelines to prevent potential health and environmental risks.

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Relevant articles and documents

A quantitative structure-reactivity assessment of phenols by investigation of rapid iodination kinetics using hydrodynamic voltammetry: Applicability of the Hammett equation in aqueous medium

Halogenations of aromatic substrates in aqueous medium are essentially electrophilic substitutions proceeding at rates concomitant with the nature of the substrates and substituent motifs. Kinetics as an investigatory tool for the quantitative assessment of the structure-reactivity correlation in these reactions for a diverse range of substrates has rarely been reported, presumably due to the rapidity of these reactions in aqueous medium. We have used hydrodynamic voltammetry to investigate the rapid kinetics of uncatalyzed iodination of phenol and eight substituted phenols by iodine monochloride at constant pH in aqueous medium. The Arrhenius plots for these reactions yield comprehensive kinetic and thermodynamic data. The quantitative structure-reactivity correlation stemming from the regio- and stereospecificity of the substituent motifs on the substrates has been examined through the Hammett plot, which shows a negative slope of 1.87. The magnitudes of the rate constants, energies of activation, frequency factors, and entropy change obtained for the nine fast reactions reported, reflect the relative ease of the reaction dynamics in quantitative terms thereby ascertaining the relative reactivities of the phenols studied herein.