855776-92-0Relevant articles and documents
Calcitonin gene-related peptide (CGRP) receptor antagonists: Pyridine as a replacement for a core amide group
Luo, Guanglin,Chen, Ling,Civiello, Rita,Pin, Sokhom S.,Xu, Cen,Kostich, Walter,Kelley, Michelle,Conway, Charles M.,MacOr, John E.,Dubowchik, Gene M.
scheme or table, p. 2917 - 2921 (2012/06/04)
In our continuing efforts to identify CGRP receptor antagonists that can be dosed orally for the treatment of migraine headache, we have investigated a pyridine bioisosteric replacement of a polar amide portion of a previous lead compound, BMS-694153. Pyr