85583-38-6

Basic information

• Product Name: 4-[2-(4-methyl-2-pyridyl)ethoxy]aniline
• Synonyms: 4-[2-(4-methyl-2-pyridyl)ethoxy]aniline
• CAS NO: 85583-38-6
• Molecular Weight: 228.294
• Mol File: 85583-38-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[2-(4-methyl-2-pyridyl)ethoxy]aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(4-methyl-2-pyridyl)ethoxy]aniline(85583-38-6)
• EPA Substance Registry System: 4-[2-(4-methyl-2-pyridyl)ethoxy]aniline(85583-38-6)

Safety Data

• Hazardous Substances Data: 85583-38-6(Hazardous Substances Data)

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 4664-18-0 2-(4-methyl-pyridin-2-yl)-ethanol 
• 85583-52-4 4-Methyl-2-[2-(4-nitro-phenoxy)-ethyl]-pyridine 

Downstream Products

• 105355-34-8 5-[4-[2-(4-methyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione 
• 105390-48-5 2-Imino-5-{4-[2-(4-methyl-pyridin-2-yl)-ethoxy]-benzyl}-thiazolidin-4-one 
• 105355-29-1 Methyl 2-bromo-3-<4-<2-(4-methyl-2-pyridyl)ethoxy>phenyl>propionate 

Relevant articles and documents

Studies on antidiabetic agents. Synthesis and hypoglycemic activity of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones

The synthesis of a series of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones is described. These compounds were evaluated for hypoglycemic and hypolipidemic activities in genetically obese and diabetic mice, yellow KK. 2-(2-Pyridyl)alkoxy derivatives were found to have much better hypoglycemic and hypolipidemic activities than 2-(3-pyridyl)- and 2-(4-pyridyl)alkoxy derivatives or even the previously reported compound, ciglitazone. The introduction of a hydroxyl group at the 2-position of the ethoxy chain potentiated the activities. Among the potent compounds, pioglitazone (AD-4833) was selected as a candidate compound.