85583-54-6Relevant articles and documents
Method for preparing 4-[2-(5-ethyl-2-pyridyl)ethyoxyl]nitrobenzene
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Paragraph 0013-0017; 0018; 0019-0024, (2018/06/21)
The invention relates to a method for preparing 4-[2-(5-ethyl-2-pyridyl)ethyoxyl]nitrobenzene. The method is characterized by comprising the following steps: dissolving 2-(5-ethyl-2-pyridyl)ethyl alcohol in halohydrocarbon, adding inorganic alkali and a p
An improved process for pioglitazone and its pharmaceutically acceptable salt
Madivada, Lokeswara Rao,Anumala, Raghupathi Reddy,Gilla, Goverdhan,Alla, Sampath,Charagondla, Kavitha,Kagga, Mukkanti,Bhattacharya, Apurba,Bandichhor, Rakeshwar
scheme or table, p. 1190 - 1194 (2010/04/22)
An improved process for pioglitazone (1) is described. The process features high-yielding transformations employing inexpensive reagents and recoverable solvents.
Structural characterization of impurities in pioglitazone
Kumar,Reddy,Eswaraiah,Mukkanti,Reddy,Suryanarayana
, p. 836 - 839 (2007/10/03)
In the pioglitazone bulk drug three prominent impurities I-III were detected up to concentrations of 0.1% (ranging from 0.05-0.1%) by reversed phase HPLC. These impurities were isolated from enriched mother liquor samples and characterized as 5-(4-hydroxybenzyl)-1,3-thiazolidine-2,4-dione (I) 5-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione (II), 2-[2-(4-bromophenoxy) ethyl-5-ethyl pyridine (III) based on their 1H, and 13C NMR, DEPT, Mass and IR spectral data. Structure elucidation and synthesis of these impurities is discussed.