85598-65-8

Basic information

• Product Name: [(3R,4S)-4-(2-Hydroxy-ethyl)-3-vinyl-piperidin-1-yl]-phenyl-methanone
• Synonyms: [(3R,4S)-4-(2-Hydroxy-ethyl)-3-vinyl-piperidin-1-yl]-phenyl-methanone
• CAS NO: 85598-65-8
• Molecular Weight: 259.348
• Mol File: 85598-65-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(3R,4S)-4-(2-Hydroxy-ethyl)-3-vinyl-piperidin-1-yl]-phenyl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [(3R,4S)-4-(2-Hydroxy-ethyl)-3-vinyl-piperidin-1-yl]-phenyl-methanone(85598-65-8)
• EPA Substance Registry System: [(3R,4S)-4-(2-Hydroxy-ethyl)-3-vinyl-piperidin-1-yl]-phenyl-methanone(85598-65-8)

Safety Data

• Hazardous Substances Data: 85598-65-8(Hazardous Substances Data)

Upstream product

• 708254-78-8 (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-[2-(2,2-dimethyl-propionyloxy)-ethyl]-piperidine-1-carboxylic acid ethyl ester 
• 708254-77-7 2,2-Dimethyl-propionic acid 2-{(3R,4S)-1-benzyl-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-piperidin-3-yl}-ethyl ester 
• 708254-76-6 2,2-Dimethyl-propionic acid (3R,4R)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-iodo-ethyl)-3-iodomethyl-hexyl ester 
• 708254-75-5 2,2-Dimethyl-propionic acid (3R,4S)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-hydroxy-ethyl)-3-hydroxymethyl-hexyl ester 
• 708254-79-9 (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidine-1-carboxylic acid ethyl ester 
• 708254-80-2 {(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidin-1-yl}-phenyl-methanone 

Downstream Products

• 35189-37-8 (+)-N-benzoylmeroquinene aldehyde 
• 56-54-2 quinindine 
• 708254-82-4 {(3R,4S)-4-[(2R,3R)-3-(6-Methoxy-quinolin-4-yl)-oxiranylmethyl]-3-vinyl-piperidin-1-yl}-phenyl-methanone 
• 708254-85-7 {(3R,4S)-4-[(2S,3S)-2,3-Dihydroxy-3-(6-methoxy-quinolin-4-yl)-propyl]-3-vinyl-piperidin-1-yl}-phenyl-methanone 
• 708254-81-3 {(3R,4S)-4-[(2R,3R)-2,3-Dihydroxy-3-(6-methoxy-quinolin-4-yl)-propyl]-3-vinyl-piperidin-1-yl}-phenyl-methanone 

Relevant articles and documents

Stereocontrolled synthesis of quinine and quinidine

Disubstituted cyclopentene was prepared from cyclopentene monoacetate and transferred into disubstituted piperidine via oxidative cleavage of the olefin moiety followed by piperidine ring formation. The piperidine was then condensed at the side chain with a quinoline part to afford the olefin precursor of quinine. Finally, the olefin was converted into quinine through the corresponding epoxide. Quinidine was synthesized in a similar way.