856453-32-2Relevant articles and documents
Processes for the preparation of isomer free prostaglandins
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Paragraph 0256; 0257; 0258, (2015/03/03)
Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
PROSTAGLANDIN SYNTHESIS
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Page/Page column 40, (2008/06/13)
A process for the preparation of prostaglandin compounds having the formula (I); wherein A is selected from the group consisting Of C1-C6 alkyl; C7-C16 aralkyl wherein the aryl group is optionally substituted with one to three substituents selected from the group consisting Of C1 -C6 alkyl, halo and CF3; and (CH2)nOR' wherein n is from 1 to 3 and R' represents a C6-Cl0 aryl group which is optionally substituted with one to three substituents selected from the group consisting Of C1-C6 alkyl, halo and CF3; B is selected from OR" and NHR" wherein R" is C1-C6 alkyl; and formula (a) represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.