856806-80-9

Basic information

• Product Name: 5-chloro-2-(methoxycarbonyl)benzoic acid
• Synonyms: 5-chloro-2-(methoxycarbonyl)benzoic acid
• CAS NO: 856806-80-9
• Molecular Weight: 214.605
• Mol File: 856806-80-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-chloro-2-(methoxycarbonyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-(methoxycarbonyl)benzoic acid(856806-80-9)
• EPA Substance Registry System: 5-chloro-2-(methoxycarbonyl)benzoic acid(856806-80-9)

Safety Data

• Hazardous Substances Data: 856806-80-9(Hazardous Substances Data)

Upstream product

• 118-45-6 4-chlorophthalic anhydride 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 90072-77-8 4-nitro-phthalic acid-1-methyl ester 
• 58138-38-8 dimethyl 4-chlorophthalate 

Downstream Products

• 1029972-01-7 4chloro-2-chlorocarbonylbenzoic acid methyl ester 
• 109702-73-0 4-Chloro-2-(2-diazo-acetyl)-benzoic acid methyl ester 
• 583835-18-1 6-bromo-2-(4-methanesulfonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbaldehyde 

Relevant articles and documents

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1)

A novel series of 4-phenylisoquinolones were synthesized and evaluated as c-Jun N-terminal kinase (JNK) inhibitors. Initial modification at the 2- and 3-positions of the isoquinolone ring of hit compound 4, identified from high-throughput screening, led to the lead compound 6b. The optimization was carried out using a JNK1-binding model of 6b and several compounds exhibited potent JNK inhibition. Among them, 11g significantly inhibited cardiac hypertrophy in rat pressure-overload models without affecting blood pressure and the concept of JNK inhibitors as novel therapeutic agents for heart failure was confirmed.