856851-28-0

Basic information

• Product Name: 4-chloro-2-(4-methoxyphenyl)pyridine
• Synonyms: 4-chloro-2-(4-methoxyphenyl)pyridine
• CAS NO: 856851-28-0
• Molecular Weight: 219.671
• Mol File: 856851-28-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-chloro-2-(4-methoxyphenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-(4-methoxyphenyl)pyridine(856851-28-0)
• EPA Substance Registry System: 4-chloro-2-(4-methoxyphenyl)pyridine(856851-28-0)

Safety Data

• Hazardous Substances Data: 856851-28-0(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 1215072-60-8 6-(4-methoxyphenyl)-pyridin-4-ylamine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 40673-25-4 4-chloro-2-hydroxypyridine 
• 26452-80-2 2,4-dichloropyridine 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 104-94-9 4-methoxy-aniline 
• 14774-77-7 p-methoxyphenyllithium 
• 5957-90-4 4-(2-pyridinyl)anisole 
• 696-62-8 para-iodoanisole 
• 139585-50-5 4-chloro-2-trimethylsilylpyridine 
• 36710-80-2 2-(4-methoxyphenyl)pyridine N-oxide  

Downstream Products

• 5957-90-4 4-(2-pyridinyl)anisole 
• 36710-80-2 2-(4-methoxyphenyl)pyridine N-oxide  
• 78296-78-3 4-Chloro-6-(4-methoxy-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide 
• 86696-44-8 4-Chloro-6-(4-methoxy-phenyl)-pyridine-2-carboxylic acid 

Relevant articles and documents

Deaminative chlorination of aminoheterocycles

Selective modification of heteroatom-containing aromatic structures is in high demand as it permits rapid evaluation of molecular complexity in advanced intermediates. Inspired by the selectivity of deaminases in nature, herein we present a simple methodology that enables the NH2 groups in aminoheterocycles to be conceived as masked modification handles. With the aid of a simple pyrylium reagent and a cheap chloride source, C(sp2)?NH2 can be converted into C(sp2)?Cl bonds. The method is characterized by its wide functional group tolerance and substrate scope, allowing the modification of >20 different classes of heteroaromatic motifs (five- and six-membered heterocycles), bearing numerous sensitive motifs. The facile conversion of NH2 into Cl in a late-stage fashion enables practitioners to apply Sandmeyer- and Vilsmeier-type transforms without the burden of explosive and unsafe diazonium salts, stoichiometric transition metals or highly oxidizing and unselective chlorinating agents. [Figure not available: see fulltext.]

Cross-coupling study of iodo/chloropyridines and 2-chloroquinoline with atom-economic triarylbismuth reagents under Pd-catalysis

This study describes the palladium-catalyzed couplings of iodopyridines, chloropyridines, and chloroquinoline with atom-economic BiAr3 reagents in sub-stoichiometric loadings. Mono-arylations of iodo and chloropyridines produced arylpyridines i

Scope and limitation for FeSO4-mediated direct arylation of heteroarenes with arylboronic acids and its synthetic applications

FeSO4-mediated direct arylation of heteroarenes with arylboronic acids in the presence of K2S2O8 has been developed. A slow addition of an aqueous solution of an iron complex was crucial in the arylation. Scope and limitation of the heteroarenes and arylboronic acids are discussed. Furthermore, the direct arylation was applied to the formal total synthesis botryllazine B and sodium channel inhibitor.