857000-47-6Relevant articles and documents
Substituted aminopyrimidine compounds and their method and use thereof
-
Paragraph 1117; 1118; 1119; 1120, (2017/12/28)
The invention relates to a new aminopyrimidine compound and an application thereof as a drug for treating disorder or diseases related to PI3-kinase abnormity in a free form or a pharmaceutically acceptable salt and preparation form. The invention also relates to a pharmaceutical composition which contains the new aminopyrimidine compound and an application of the pharmaceutical composition in treating mammal disorder or diseases and especially treating human disorder or diseases related to the PI3-kinase abnormity, such as treatment of immunity and inflammatory diseases of PI3-kinase regulation which plays a leading role in a leucocyte function and treatment of proliferative diseases which are related to PI3-kinase activity and include but not limited to leukaemia and solid tumor.
A novel highly stereoselective synthesis of 2,3-disubstituted 3H-quinazoline-4-one derivatives
Zhichkin, Paul,Kesicki, Edward,Treiberg, Jennifer,Bourdon, Lisa,Ronsheim, Matthew,Ooi, Hua Chee,White, Stephen,Judkins, Angela,Fairfax, David
, p. 1415 - 1418 (2007/10/03)
Figure presented An efficient three-step synthesis of chiral 3H-quinazoline-4-one derivatives from commercial materials is disclosed. The Mumm reaction of imidoyl chloride with α-amino acids followed by reductive cyclization affords enantiomerically pure (ee >93%) quinazoline-4-ones in good overall yield. A comparison with existing approaches indicates that this method is superior for hindered substrates.
