85702-70-1

Basic information

• Product Name: 5-CHLORO-2-METHYLAMINOBENZONITRILE
• Synonyms: 5-CHLORO-2-METHYLAMINOBENZONITRILE
• CAS NO: 85702-70-1
• Molecular Formula: C₈H₇ClN₂
• Molecular Weight: 166.61
• EINECS: 288-260-3
• Product Categories: Aromatic Nitriles
• Mol File: 85702-70-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 310.8 °C at 760 mmHg
• Flash Point: 141.8 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 0.000585mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 5-CHLORO-2-METHYLAMINOBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-METHYLAMINOBENZONITRILE(85702-70-1)
• EPA Substance Registry System: 5-CHLORO-2-METHYLAMINOBENZONITRILE(85702-70-1)

Safety Data

• Hazardous Substances Data: 85702-70-1(Hazardous Substances Data)

Usage

General Description

5-CHLORO-2-METHYLAMINOBENZONITRILE is an organic chemical compound with the molecular formula C8H7ClN2. It is a pale yellow solid, primarily used as an intermediate in the production of pharmaceuticals and agrochemicals. 5-CHLORO-2-METHYLAMINOBENZONITRILE is a benzocyanine derivative, and its structure contains a chlorine atom, a methylamine group, and a nitrile group. It is commonly utilized in the synthesis of various pharmaceuticals, including anti-inflammatory drugs and antimalarial agents. Additionally, 5-CHLORO-2-METHYLAMINOBENZONITRILE is employed in the manufacturing of agricultural chemicals, serving as a building block for herbicides and insecticides. Due to its importance in the production of pharmaceutical and agricultural products, this chemical compound is of significant interest to the chemical industry.

InChI:InChI=1/C8H7ClN2/c1-11-8-3-2-7(9)4-6(8)5-10/h2-4,11H,1H3

Upstream product

• 553-90-2 Dimethyl oxalate 
• 5922-60-1 2-amino-5-chlorobenzonitrile 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 1007-19-8 4-chloro-N-methyl-N-nitrosoaniline 
• 74-89-5 methylamine 
• 57381-34-7 5-chloro-2-fluorobenzonitrile 

Downstream Products

• 106874-97-9 N-(2-bromopropionyl)-5-chloro-N-methyl-2-cyanoaniline 
• 1294507-91-7 C₁₆H₁₁ClN₂O 

Relevant articles and documents

Nickel/Photo-Cocatalyzed Asymmetric Acyl-Carbamoylation of Alkenes

An unprecedented asymmetric acyl-carbamoylation of pendant alkenes tethered on aryl carbamic chlorides with both aliphatic and aromatic aldehydes has been developed via the cooperative catalysis of a chiral nickel-PHOX complex and tetrabutylammonium decatungstate. This reaction represents the first example of merging hydrogen-atom-transfer photochemistry and asymmetric transition metal catalysis in difunctionalization of alkenes. Using this protocol, a variety of oxindoles bearing a challenging quaternary stereogenic center are furnished under mild conditions in highly enantioselective manner.

A NEW SYNTHESIS OF 4-AMINO-2-QUINOLINONES

Addition of Grignard or organolithium reagents to N-(α-haloacyl)-N-alkylsubstituted anthranilonitriles (e.g.N-(2-bromopropionyl)-N-methyl-2-cyanoaniline)induced anion formation followed by cyclization to 4-amino-2-quinolinones (e.g. 4-amino-1,3-dimethyl-2-quinolinone (10)).Substrates lacking α-hydrogen atoms, such as N-α-bromoisobutyryl)-2-cyanoaniline, also yielded 3,3-dimethylquinolinedione (9b) by cyclization.In these cases the initial step is a halogen-metal exchange reaction.