857083-15-9

Basic information

• Product Name: tert-butyl 2-{(9S,10S,18S,14R)-7,16,19-triaza-10-[4-(tert-butoxy)phenyl]-18-(carbamoylmethyl)-14-[(5-methylindolyl)methyl]-8,17,20-trioxospiro[5.14]icos-11-en-9-yl}acetate
• Synonyms: tert-butyl 2-{(9S,10S,18S,14R)-7,16,19-triaza-10-[4-(tert-butoxy)phenyl]-18-(carbamoylmethyl)-14-[(5-methylindolyl)methyl]-8,17,20-trioxospiro[5.14]icos-11-en-9-yl}acetate
• CAS NO: 857083-15-9
• Molecular Weight: 784.009
• Mol File: 857083-15-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-{(9S,10S,18S,14R)-7,16,19-triaza-10-[4-(tert-butoxy)phenyl]-18-(carbamoylmethyl)-14-[(5-methylindolyl)methyl]-8,17,20-trioxospiro[5.14]icos-11-en-9-yl}acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-{(9S,10S,18S,14R)-7,16,19-triaza-10-[4-(tert-butoxy)phenyl]-18-(carbamoylmethyl)-14-[(5-methylindolyl)methyl]-8,17,20-trioxospiro[5.14]icos-11-en-9-yl}acetate(857083-15-9)
• EPA Substance Registry System: tert-butyl 2-{(9S,10S,18S,14R)-7,16,19-triaza-10-[4-(tert-butoxy)phenyl]-18-(carbamoylmethyl)-14-[(5-methylindolyl)methyl]-8,17,20-trioxospiro[5.14]icos-11-en-9-yl}acetate(857083-15-9)

Safety Data

• Hazardous Substances Data: 857083-15-9(Hazardous Substances Data)

Upstream product

• 857083-14-8 tert-butyl 3-[N-({N-1-(N-{(2R)-2-[(5-methylindolyl)methyl]pent-4-enyl}-(1S)-2-carbamoylethyl)carbamoyl}cyclohexyl)carbamoyl]-(3S,4S)-4-[4-(tert-butoxy)phenyl]hex-5-enoate 
• 60876-70-2 4-tert-butoxybromobenzene 
• 106-41-2 4-bromo-phenol 
• 857083-11-5 tert-butyl 3-[((4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)carbonyl](3R,4S)-4-[4-(tert-butoxy)phenyl]hex-5-enoate 
• 857083-10-4 (3R,4S)-3-[(tert-butoxy)phenyl]pent-4-enoyl-4-phenyl-1,3-oxazolidin-2-one 
• 857083-09-1 (4S)-3-{(2E)-3-[(tert-butoxy)phenyl]prop-2-enoyl}-4-phenyl-1,3-oxazolidin-2-one 
• 857083-12-6 (2S,3S)-2-{[(tert-butyl)oxycarbonyl]methyl}-3-[4-(tert-butoxy)phenyl]pent-4-enoic acid 

Relevant articles and documents

Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform

Reported herein are the design, synthesis, and Grb2 SH2 domain-binding affinities of several phosphoryl-mimicking groups displayed within the context of a conformationally constrained macrocyclic platform. With use of surface plasmon resonance techniques, single-digit nanomolar affinities were exhibited by phosphonic acid and malonyl-containing diacidic phosphoryl mimetics (for 4h and 4g, KD = 1.47 and 3.62 nM, respectively). Analogues containing monoacidic phosphoryl mimetics provided affinities of KD = 16-67 nM. Neutral phosphoryl-mimicking groups did not show appreciable binding.