857284-25-4 Usage
Description
[2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL is a chemical compound with the molecular formula C11H8F3NOS. It is a thiazole derivative that features a trifluoromethylphenyl group and a methanol group. [2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL is known for its unique structure and properties, which may have potential applications in various fields such as pharmaceuticals and agrochemicals. The presence of the trifluoromethyl group, which is an electron-withdrawing moiety, can enhance the pharmacokinetic properties of drug molecules. Furthermore, the thiazole ring is recognized for its wide range of biological activities, making this compound a promising building block for the development of new drug candidates.
Uses
Used in Pharmaceutical Industry:
[2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL is used as a building block for the development of new drug candidates due to its unique structure and properties. [2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL's trifluoromethyl group can improve the pharmacokinetic properties of drug molecules, while the thiazole moiety exhibits a broad spectrum of biological activities, making it a valuable component in the creation of novel pharmaceuticals.
Used in Agrochemical Industry:
In the agrochemical industry, [2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL may be utilized as a starting material or intermediate for the synthesis of various agrochemical products. Its unique structure and properties can potentially contribute to the development of new pesticides, herbicides, or other agrochemicals with improved efficacy and selectivity.
Further investigation and research into the properties and potential applications of [2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL are warranted to fully understand its capabilities and maximize its utility in these industries.
Check Digit Verification of cas no
The CAS Registry Mumber 857284-25-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,7,2,8 and 4 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 857284-25:
(8*8)+(7*5)+(6*7)+(5*2)+(4*8)+(3*4)+(2*2)+(1*5)=204
204 % 10 = 4
So 857284-25-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H8F3NOS/c12-11(13,14)8-3-1-7(2-4-8)10-15-9(5-16)6-17-10/h1-4,6,16H,5H2
857284-25-4Relevant articles and documents
Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells
Dang, Xin,Lei, Shuwen,Luo, Shuhua,Hu, Yixin,Wang, Juntao,Zhang, Dongdong,Lu, Dan,Jiang, Faqin,Fu, Lei
, (2021/06/16)
Mitochondria are pivotal energy production sources for cells to maintain necessary metabolism activities. Targeting dysfunctional mitochondrial features has been a hotspot for mitochondrial-related disease researches. Investigation with cancerous mitochondrial metabolism is a continuing concern within tumor therapy. Herein, we set out to assess the anti-cancer activities of a novel family of TPP-thiazole derivatives based on our earlier research on mitochondrial targeting agents. Specifically, we designed and synthesized a series of TPP-thiazole derivatives and revealed by the MTT assay that most synthesized compounds effectively inhibited three cancer cell lines (HeLa, PC3 and MCF-7). After structure modifications, we explored the SAR relationships and identified the most promising compound R13 (IC50 of 5.52 μM) for further investigation. In the meantime, we performed ATP production assay to assess the selected compounds inhibitory effect on HeLa cells energy production. The results displayed the test compounds significantly restrained ATP production of cancer cells. Overall, we have designed and synthesized a series of compounds which exhibited significant cytotoxicity against cancer cells and effectively inhibited mitochondrial energy production.
Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols
Xia, Anjie,Qi, Xueyu,Mao, Xin,Wu, Xiaoai,Yang, Xin,Zhang, Rong,Xiang, Zhiyu,Lian, Zhong,Chen, Yingchun,Yang, Shengyong
, (2019/05/07)
A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.
