857550-48-2

Basic information

• Product Name: 1-(2-amino-5-bromo-phenyl)-1-phenyl-ethanol
• CAS NO: 857550-48-2
• Molecular Weight: 292.175
• Mol File: 857550-48-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2-amino-5-bromo-phenyl)-1-phenyl-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-amino-5-bromo-phenyl)-1-phenyl-ethanol(857550-48-2)
• EPA Substance Registry System: 1-(2-amino-5-bromo-phenyl)-1-phenyl-ethanol(857550-48-2)

Safety Data

• Hazardous Substances Data: 857550-48-2(Hazardous Substances Data)

Upstream product

• 29124-56-9 1-(2-amino-5-bromophenyl)ethanone 

Downstream Products

• 189252-18-4 1-phenyl-1-(2-amino-5-bromophenyl)ethylene 

Relevant articles and documents

Potent nonsteroidal progesterone receptor agonists: Synthesis and SAR study of 6-aryl benzoxazines

Novel 6-aryl benzoxazines were prepared and examined as progesterone receptor (PR) modulators. In contrast to the structurally related 6-aryl dihydroquinoline PR antagonists, the 6-aryl benzoxazines were potent PR agonists. Compounds 4e, 5b, and 6a with the 2,4,4-trimethyl-1,4-dihydro-2H-benzo[d][1,3]oxazine core were the most potent PR agonists in the series with sub-nanomolar activities (EC50 0.20-0.35 nM). Compound 6a was more potent than progesterone (P4) in the in vivo decidualization assay in an ovariectomized female rat model by subcutaneous administration with an ED50 of 1.5 mg/kg (vs 5.62 mg/kg for P4).