857651-06-0 Usage
General Description
4-hydroxy-4-(5-(pyrimidin-2-yl)pyridine-2-yl) cyclohexanone is a chemical compound with the molecular formula C16H15N3O2. It is a derivative of cyclohexanone with substituents including a hydroxyl group and a pyridine ring. 4-hydroxy-4-(5-(pyrimidin-2-yl)pyridine-2-yl) cyclohexanone is a key intermediate in the synthesis of pharmaceuticals and agrochemicals, and it also has potential applications in the field of materials science. Its structural features make it valuable for studies in organic chemistry and for the development of new synthetic routes. Additionally, the presence of a pyrimidine moiety in its structure suggests potential biological activity, making it a subject of interest for drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 857651-06-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,7,6,5 and 1 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 857651-06:
(8*8)+(7*5)+(6*7)+(5*6)+(4*5)+(3*1)+(2*0)+(1*6)=200
200 % 10 = 0
So 857651-06-0 is a valid CAS Registry Number.
857651-06-0Relevant articles and documents
Discovery of INCB8761/PF-4136309, a potent, selective, and orally bioavailable CCR2 antagonist
Xue, Chu-Biao,Wang, Anlai,Han, Qi,Zhang, Yingxin,Cao, Ganfeng,Feng, Hao,Huang, Taisheng,Zheng, Changsheng,Xia, Michael,Zhang, Ke,Kong, Lingquan,Glenn, Joseph,Anand, Rajan,Meloni, David,Robinson,Shao, Lixin,Storace, Lou,Li, Mei,Hughes, Robert O.,Devraj, Rajesh,Morton, Philip A.,Rogier, D. Joseph,Covington, Maryanne,Scherle, Peggy,Diamond, Sharon,Emm, Tom,Yeleswaram, Swamy,Contel, Nancy,Vaddi, Kris,Newton, Robert,Hollis, Greg,Metcalf, Brian
, p. 913 - 918 (2012/02/13)
We report the discovery of a new (S)-3-aminopyrrolidine series of CCR2 antagonists. Structure-activity relationship studies on this new series led to the identification of 17 (INCB8761/PF-4136309) that exhibited potent CCR2 antagonistic activity, high sel
