85817-60-3

Basic information

• Product Name: 2-CHLORO-N-(5-CHLORO-2-METHYL-PHENYL)-ACETAMIDE
• Synonyms: ZERENEX E/5016851;CHEMBRDG-BB 3015661;ART-CHEM-BB B015661;ASISCHEM R08628;AKOS B015661;AKOS BBS-00004059;2-CHLORO-N-(5-CHLORO-2-METHYL-PHENYL)-ACETAMIDE;Nsc37258
• CAS NO: 85817-60-3
• Molecular Formula: C₉H₉Cl₂NO
• Molecular Weight: 218.08
• Mol File: 85817-60-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 353°Cat760mmHg
• Flash Point: 167.3°C
• Appearance: /
• Density: 1.345g/cm³
• Vapor Pressure: 3.69E-05mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 2-CHLORO-N-(5-CHLORO-2-METHYL-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-(5-CHLORO-2-METHYL-PHENYL)-ACETAMIDE(85817-60-3)
• EPA Substance Registry System: 2-CHLORO-N-(5-CHLORO-2-METHYL-PHENYL)-ACETAMIDE(85817-60-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 85817-60-3(Hazardous Substances Data)

Usage

Description

2-CHLORO-N-(5-CHLORO-2-METHYL-PHENYL)-ACETAMIDE is a chemical compound with the molecular formula C9H8Cl2NO. It is a derivative of acetamide and contains chloro and methyl groups. This amide is primarily used in the pharmaceutical industry for its potential as an antifungal agent. Additionally, it has also been studied for its potential use in the treatment of various neurological disorders. The presence of chloro and methyl groups in the compound's structure gives it certain properties and activities that make it an important molecule in medicinal chemistry and drug development.

Uses

Used in Pharmaceutical Industry:
2-CHLORO-N-(5-CHLORO-2-METHYL-PHENYL)-ACETAMIDE is used as an antifungal agent for its potential to combat fungal infections. Its unique structure, featuring chloro and methyl groups, contributes to its antifungal properties, making it a valuable compound in the development of new antifungal medications.
Used in Neurological Disorder Treatment:
2-CHLORO-N-(5-CHLORO-2-METHYL-PHENYL)-ACETAMIDE is also being studied for its potential use in the treatment of various neurological disorders. 2-CHLORO-N-(5-CHLORO-2-METHYL-PHENYL)-ACETAMIDE's specific structural features may offer therapeutic benefits in managing or treating such conditions, although further research is needed to fully understand its applications in this area.

InChI:InChI=1/C9H9Cl2NO/c1-6-2-3-7(11)4-8(6)12-9(13)5-10/h2-4H,5H2,1H3,(H,12,13)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 95-79-4 5-chloro-2-methyl-benzenamine 

Downstream Products

• 332909-18-9 piperidino-acetic acid-(5-chloro-2-methyl-anilide) 
• 110063-03-1 1-[(5-chloro-2-methyl-phenylcarbamoyl)-methyl]-pyridinium; chloride 
• 500345-88-0 N-(5-chloro-2-methylphenyl)-2-(ethylamino)acetamide 
• 919422-91-6 C₁₆H₁₄ClN₅O 
• 937862-11-8 C₁₆H₁₄ClN₅O 
• 332912-24-0 C₂₈H₂₂ClN₃O₂S 

Relevant articles and documents

Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors

Thirty-eight disulfides containing N-arylacetamide were designed and synthesized in an effort to develop novel urease inhibitors. Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against both cell-free urease and urease in intact cell with low cytotoxicity to mammalian cells even at concentration up to 250 μM. Of note, 2,2′-dithiobis(N-(2-fluorophenyl)acetamide) (d7), 2,2′-dithiobis(N-(3,5-difluorophenyl)acetamide) (d24), and 2,2′-dithiobis(N-(3-fluorophenyl)acetamide) (d8) were here identified as the most active inhibitors with IC50 of 0.074, 0.44, and 0.81 μM, showing 32- to 355-fold higher potency than the positive control acetohydroxamic acid. These disulfides were confirmed to bind urease without covalent modification of the cysteine residue and to inhibit urease reversibly with a mixed inhibition mechanism. They also showed very good anti-Helicobacter pylori activities with d8 showing a comparable potency to the clinical used drug amoxicillin. The impressive in vitro biological profile indicated their immense potential as therapeutic agents to tackle H. pylori caused infections.

Acetamides and benzamides that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia

Novel N-aryl-piperazinealkanamides, having particular substituents attached to one of the carbon atoms of the piperazine ring, which compounds are useful to protect hearts from myocardial injury caused by ischaemia, anoxia or hypoxia.