85862-90-4

Basic information

• Product Name: 1-(4-(1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one
• Synonyms: 1-(4-(1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one
• CAS NO: 85862-90-4
• Molecular Weight: 187.201
• Mol File: 85862-90-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-(4-(1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one(85862-90-4)
• EPA Substance Registry System: 1-(4-(1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one(85862-90-4)

Safety Data

• Hazardous Substances Data: 85862-90-4(Hazardous Substances Data)

Upstream product

• 108-05-4 vinyl acetate 
• 20062-24-2 4-azidoacetophenone 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 288-36-8 1 ,2,3-Triazole 
• 99-92-3 p-aminobenzophenone 
• 288-36-8 1,2,3-triazole 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 128864-42-6 2-Bromo-1-(4-[1,2,3]triazol-1-yl-phenyl)-ethanone 
• 128864-44-8 1-(p-dibromoacetyl-phenyl)-1H-1,2,3-triazole 
• 128864-38-0 di-<-carbonylmethylen> disulfide 

Relevant articles and documents

[4 + 1] Annulation of in situ generated azoalkenes with amines: A powerful approach to access 1-substituted 1,2,3-triazoles

1-Substituted 1,2,3-triazoles represents ‘privileged’ structural scaffolds of many clinical pharmaceuticals. However, the traditional methods for their preparation mainly rely on thermal [3 + 2] cycloaddition of potentially dangerous acetylene and azides. Here we report a base-mediated [4 + 1] annulation of azoalkenes generated in situ from readily available difluoroacetaldehyde N-tosylhydrazones (DFHZ-Ts) with amines under relatively mild conditions. This azide- and acetylene-free strategy provides facile access to diverse 1-substituted 1,2,3-triazole derivatives in high yield in a regiospecific manner. This transformation has great functional group tolerance and can suit a broad substrate scope. Furthermore, the application of this novel methodology in the gram-scale synthesis of an antibiotic drug PH-027 and in the late-stage derivatization of several bioactive small molecules and clinical drugs demonstrated its generality, practicability and applicability.

Single-component small-molecule white light organic phosphors

White light emission from single-component small organic triazole molecules in the solid state was observed for the first time. This unusual intrinsic broadband emission, stemming from the supramolecular aggregate instead of the excimer, can be tuned by c

Synthesis and antifungal activity of novel thiazole-containing triazole antifungals. II. Optically active ER-30346 and its derivatives

A series of novel thiazole-containing triazole antifungals was synthesized and evaluated for antifungal activity against a variety of clinically isolated pathogenic fungi in vitro and against systemic candidosis in vivo. These compounds showed potent antifungal activities in vitro and in vivo. In particular, (2R,3R)-3-[4-(4-cyanophenyl)thiazol-2-yl]-2-(2,4- difluorophenyl)-1-(1H-1,2,4-triazol-l-yl)-2-butanol (12g; ER-30346) showed potent and well-balanced in vitro activities and potent in vivo efficacy, and had a good safety profile.