85865-57-2

Basic information

• Product Name: 2-(Methoxycarbonyl)-3-methoxyacetophenone
• Synonyms: 2-(Methoxycarbonyl)-3-methoxyacetophenone
• CAS NO: 85865-57-2
• Molecular Weight: 208.214
• Mol File: 85865-57-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(Methoxycarbonyl)-3-methoxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Methoxycarbonyl)-3-methoxyacetophenone(85865-57-2)
• EPA Substance Registry System: 2-(Methoxycarbonyl)-3-methoxyacetophenone(85865-57-2)

Safety Data

• Hazardous Substances Data: 85865-57-2(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 99512-66-0 O-acetyl-salicylic acid 
• 179678-24-1 2-acetyl-6-methoxy-benzoic acid 
• 74-88-4 methyl iodide 
• 99184-73-3 2-acetyl-6-methoxy-benzonitrile 
• 4938-06-1 7-Methoxy-3-methylphthalide 
• 85882-85-5 (3-Methoxyacetophenone ethylene acetal)chromium Tricarbonyl 
• 79-22-1 methyl chloroformate 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 136192-85-3 methyl 1-hydroxy-6-acetylbenzoate 
• 179678-24-1 2-acetyl-6-methoxy-benzoic acid 

Relevant articles and documents

Studies of the New Herbicide KIH-6127. Part I. Novel Synthesis of Methyl 6-Acetylsalicylate as a Key Synthetic Intermediate for the Preparation of 6-Acetyl Pyrimidin-2-yl Salicylates and Analogues

A novel synthesis of methyl 6-acetylsalicylate as a key synthetic intermediate for methyl 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-[1-(methoxyimino)ethyl]benzoate (KIH-6127) was studied, and directed at 6-substituted pyrimidin-2-yl salicylate herbicides and their analogues. Three synthetic approaches were successful: a modification of the Sandmeyer reaction of 6-acetylanthranilate (Method A), a direct ring-opening reaction of 3-methylphthalide using potassium permanganate, and magnesium nitrate (Method B), and a regioselective ortholithiation of the protected 3-hydroxyacetophenone (Method C). These methods were applicable for the synthesis of various 6-acyl salicylates.