85878-84-8 Usage
General Description
4-CHLORO-6-(CHLOROMETHYL)-PYRIMIDINE is a chemical compound with the molecular formula C5H4Cl2N2. It is a chlorinated pyrimidine derivative that is used in the synthesis of pharmaceuticals, agrochemicals, and dyes. 4-CHLORO-6-(CHLOROMETHYL)-PYRIMIDINE is a white to light yellow solid with a melting point of 74-75°C and is sparingly soluble in water but soluble in organic solvents. It is primarily utilized as an intermediate in the production of various pesticides and herbicides, as well as in the development of pharmaceutical drugs. Its chloromethyl group makes it a versatile building block for the synthesis of a wide range of biologically active compounds. Additionally, it is also used as a reagent in organic synthesis reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 85878-84-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,8,7 and 8 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 85878-84:
(7*8)+(6*5)+(5*8)+(4*7)+(3*8)+(2*8)+(1*4)=198
198 % 10 = 8
So 85878-84-8 is a valid CAS Registry Number.
85878-84-8Relevant articles and documents
Synthesis of Homo-C-nucleosides using Pyrimidinylmethylenephosphoranes
Katagiri, Nobuya,Takashima, Kenichi,Kato, Tetsuzo,Sato, Sadao,Tamura, Chihiro
, p. 201 - 209 (2007/10/02)
The direct synthesis of homo-C-nucleosides from pyrimidinylmethylenephosphoranes and protected D-ribose is described.Reaction of 2,3-O-isopropylidene-5-O-trityl-D-ribose (9) with pyrimidinylmethylenephosphoranes (5)-(8) gave protected α-and β-homo-C-nucleosides (14)-(21) and pyrimidinylolefins (10)-(13) in good yields.The ratio of α- and β-nucleosides depended on the properties of phosphoranes.Treatment of compounds (10)-(13) with base such as triethylamine or 1,8-diazabicycloundec-7-ene (DBU) gave ring-closed products (14)-(21) in quantitative yields.Deprotection of compounds (14)-(21) with hydrochloric acid in either dioxane-water or methanol gave homo-C-nucleosides (22)-(32).
